Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
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DOI：
10.1371/journal.pbio.0040046
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发表时间：
2006-03
期刊：
影响因子：
9.8
通讯作者：
Miller RD
中科院分区：
文献类型：
--
作者：
Belov K;Deakin JE;Papenfuss AT;Baker ML;Melman SD;Siddle HV;Gouin N;Goode DL;Sargeant TJ;Robinson MD;Wakefield MJ;Mahony S;Cross JG;Benos PV;Samollow PB;Speed TP;Graves JA;Miller RD
第一个测序的有袋动物基因组有望揭示哺乳动物进化的无与伦比的见解。我们已经使用Monodelphis astritica（灰色短尾负鼠）序列构建了有袋动物主要组织相容性复合体（MHC）的第一个图谱。MHC是哺乳动物基因组中基因密度最大的区域，对免疫和生殖成功至关重要。有袋动物MHC弥补了真兽目哺乳动物复杂MHC和鸟类最低必需MHC之间的系统发育差距。在这里，我们表明，负鼠的MHC基因密集和复杂，在人类中，但与非哺乳动物共享更多的组织特征。I类基因在II类区域内扩增，产生独特的I/II类区域。我们提出了一个模型的组织的MHC在祖先哺乳动物和哺乳动物进化过程中的阐述。负鼠基因组与其他现存基因组一起揭示了一种祖先“免疫超复合物”的存在，该复合物包含两种类型的自然杀伤受体基因以及抗原加工基因和MHC基因。负鼠基因组序列数据使研究人员能够填补我们对主要组织相容性复合体如何在哺乳动物谱系中进化的知识空白。
The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used theMonodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral “immune supercomplex” that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Opossum genomic sequence data permit researchers to fill gaps in our knowledge of how the Major Histocompatibility Complex evolved within the mammalian lineage.
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影响因子：
3.2
作者：
Miska, KB;Miller, RD
通讯作者：
Miller, RD
影响因子：
5.8
作者：
Boss, JM
通讯作者：
Boss, JM
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
1.5
作者：
Kelley, J;Trowsdale, J
通讯作者：
Trowsdale, J
影响因子：
1.7
作者：
Gouin, N;Deakin, JE;Samollow, PB
通讯作者：
Samollow, PB