Human infections with non-O157 Shiga toxin-producing Escherichia coli, Switzerland, 2000-2009.

Human infections with non-O157 Shiga toxin-producing Escherichia coli, Switzerland, 2000-2009.
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非O157志贺毒素产生的大肠杆菌的人类感染,瑞士,2000年至2009年。

DOI:
10.3201/eid1702.100909
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发表时间:
2011-02
影响因子:
11.8
通讯作者:
Stephan R
Stephan R
中科院分区:
医学2区
文献类型:
--
作者:
Käppeli U;Hächler H;Giezendanner N;Beutin L;Stephan R

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我们对2000-2009年从瑞士国家参考实验室分离的97株非O 157滋贺毒素(stx)产大肠杆菌菌株进行了鉴定。结果表明,分离菌株分属O:H血清型40种,其中O26:H11/H-、O 103:H2、O 121:H19和O 145:H28/H-4种血清型占分离菌株总数的46.4%。23.2%的患者报告非血性腹泻,56.8%的患者报告血性腹泻。40.0%的患者发生溶血性尿毒综合征;血清型O26:H11/H-最常与该综合征相关。45株(46.4%)仅携带stx 2基因,36株(37.1%)携带stx 1基因,16株(16.5%)同时携带stx 1和stx 2基因。肠溶血素基因和内膜粘附素基因的检出率分别为75.3%和70.1%。25株菌对1种以上抗菌药物耐药。菌株间的高度遗传多样性表明非O 157产stx的E.瑞士的大肠杆菌感染大多数发生在单一病例中。
We characterized 97 non-O157 Shiga toxin (stx)–producing Escherichia coli strains isolated from human patients during 2000–2009 from the national reference laboratory in Switzerland. These strains belonged to 40 O:H serotypes; 4 serotypes (O26:H11/H–, O103:H2, O121:H19, and O145:H28/H–) accounted for 46.4% of the strains. Nonbloody diarrhea was reported by 23.2% of the patients, bloody diarrhea by 56.8%. Hemolytic uremic syndrome developed in 40.0% of patients; serotype O26:H11/H– was most often associated with this syndrome. Forty-five (46.4%) strains carried stx2 genes only, 36 strains (37.1%) carried stx1, and 16 (16.5%) strains carried stx1 and stx2. Genes encoding enterohemolysin and intimin were detected in 75.3% and 70.1% of the strains, respectively. Resistance to >1 antimicrobial agent was present in 25 isolates. High genetic diversity within strains indicates that non-O157 stx–producing E. coli infections in Switzerland most often occurred as single cases.
DOI: 10.1128/jcm.42.1.311-319.2004
发表时间: 2004-01-01
影响因子: 9.4
作者:
Blanco, JE;Blanco, M;Blanco, J
通讯作者: Blanco, J
DOI: 10.1128/jcm.41.11.4930-4940.2003
发表时间: 2003-11-01
影响因子: 9.4
作者:
Karmali, MA;Mascarenhas, M;Kaper, JB
通讯作者: Kaper, JB
DOI: 10.1128/jcm.00201-09
发表时间: 2009-07-01
影响因子: 9.4
作者:
Bielaszewska, Martina;Stoewe, Franziska;Friedrich, Alexander W.
通讯作者: Friedrich, Alexander W.
DOI: 10.1128/jcm.37.3.497-503.1999
发表时间: 1999-03-01
影响因子: 9.4
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通讯作者: Gyles, CL
DOI: 10.1046/j.1469-0691.2002.00364.x
发表时间: 2002-03-01
影响因子: 14.2
作者:
Evans, J;Wilson, A;Smith, HR
通讯作者: Smith, HR