Estimation of individually induced e-field strength during transcranial electric stimulation using the head circumference.

Estimation of individually induced e-field strength during transcranial electric stimulation using the head circumference.
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利用头围估计经颅电刺激过程中的个体感应电场强度。

DOI:
10.1016/j.brs.2021.07.001
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发表时间:
2021-09
期刊:
影响因子:
7.7
通讯作者:
Thielscher A
Thielscher A
中科院分区:
医学1区
文献类型:
--
作者:
Antonenko D;Grittner U;Puonti O;Flöel A;Thielscher A

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头部和大脑解剖结构与经颅电刺激 (tES) 诱导的电场强度有关。基于解剖因素的个体化需要高质量的结构磁共振图像,但这并不总是可用的。头围 (HC) 可以作为替代方法,但其与电场强度的联系尚未建立。我们根据 47 名健康成年人的个人 T1w 和 T2w 图像,针对四个传统(“标准”)和四个相应的焦点(“4×1”)电极蒙太奇模拟了 tES 感应的电场。使用线性混合模型计算电场强度与个体 HC 的关联。较大的 HC 与整个蒙太奇的较低电场强度相关。我们提供数学方程来根据 HC 估计各个电场强度。 HC 可用作估计 tES 诱导电场强度的个体差异和前瞻性个体化刺激剂量的替代方案,例如在临床环境中。
Head and brain anatomy have been related to e-field strengths induced by transcranial electrical stimulation (tES). Individualization based on anatomic factors require high-quality structural magnetic resonance images, which are not always available. Head circumference (HC) can serve as an alternative means, but its linkage to electric field strength has not yet been established. We simulated electric fields induced by tES based on individual T1w- and T2w-images of 47 healthy adults, for four conventional (“standard”) and four corresponding focal (“4×1”) electrode montages. Associations of electric field strengths with individual HC were calculated using linear mixed models. Larger HC was associated with lower electric field strength across montages. We provide mathematical equations to estimate individual electric field strengths based on the HC. HC can be used as an alternative to estimate interindividual differences of the tES-induced electric field strength and to prospectively individualize stimulation dose, e.g., in the clinical context.
DOI: 10.1111/ner.13342
发表时间: 2020-12-14
期刊: NEUROMODULATION
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