In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging.
In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging.
复制标题
使用多波段SWIFT磁共振成像的骨质量和矿物质密度的体内定量成像生物标志物。
DOI：
10.1016/j.bone.2020.115615
复制
发表时间：
2021-03
期刊：
影响因子：
4.1
通讯作者：
Kozloff KM
中科院分区：
文献类型：
--
作者：
Surowiec RK;Ram S;Idiyatullin D;Goulet R;Schlecht SH;Galban CJ;Kozloff KM
骨是一种由矿物晶体、有机基质和水组成的复合生物材料。每一种都有助于骨骼质量和强度，可以独立改变，也可以随着疾病的进展和治疗而一起改变。即便如此，人们几乎无处不在地依赖于基于电离X射线的方法来测量骨密度(BMD)，这种方法不能完全表征骨强度，也不能充分预测骨折风险。由于缺乏能够安全地监测体内材料水平和生化变化的成像手段，对骨重塑改变的骨疾病的治疗效果的表征是复杂的。为了改善骨成像的现状，我们测试了多波段扫描傅立叶变换成像(MB-SWIFT)磁共振成像(MRI)作为雌激素缺乏的卵巢切除(OVX)大鼠生长过程中骨排列紊乱的读数的有效性。MB-SWIFT磁共振获得的骨密度与用微型计算机断层扫描(μCT)测量的骨密度显著相关。在这个啮齿动物模型中，生长似乎克服了雌激素缺乏，因为骨量在研究期间继续纵向增加。尽管如此，在干预10周后，MB-SWIFT检测到与雌激素缺乏一致的皮质水、皮质基质组织(T1)和骨髓脂肪的显著变化。研究结果表明，MB-SWIFT能够与μCT很好地一致地量化骨密度，同时以与雌激素缺乏一致的方式提供关于骨质量的附加定量结果。这些结果表明MB-SWIFT是一种具有骨成像价值的非电离成像技术，有望推广到临床，用于骨质疏松症等骨病患者的监测和临床治疗。
Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral density (BMD) which is unable to fully characterize bone strength and may not adequately predict fracture risk. Characterization of treatment efficacy in bone diseases of altered remodeling is complicated by the lack of imaging modality able to safely monitor material-level and biochemical changes In vivo. To improve upon the current state of bone imaging, we tested the efficacy of Multi Band SWeep Imaging with Fourier Transformation (MB-SWIFT) magnetic resonance imaging (MRI) as a readout of bone derangement in an estrogen deficient ovariectomized (OVX) rat model during growth. MB-SWIFT MRI-derived BMD correlated significantly with BMD measured using micro-computed tomography (μCT). In this rodent model, growth appeared to overcome estrogen deficiency as bone mass continued to increase longitudinally over the duration of the study. Nonetheless, after 10 weeks of intervention, MB-SWIFT detected significant changes consistent with estrogen deficiency in cortical water, cortical matrix organization (T1), and marrow fat. Findings point to MB-SWIFT’s ability to quantify BMD in good agreement with μCT while providing additive quantitative outcomes about bone quality in a manner consistent with estrogen deficiency. These results indicate MB-SWIFT as a non-ionizing imaging strategy with value for bone imaging and may be a promising technique to progress to the clinic for monitoring and clinical management of patients with bone diseases such as osteoporosis.
登录
查看更多内容
影响因子：
2.5
作者：
Rhee Y;Hur JH;Won YY;Lim SK;Beak MH;Cui WQ;Kim KG;Kim YE
通讯作者：
Kim YE
影响因子：
2.5
作者：
Berberat, Jatta E.;Nissi, Mikko J.;Nieminen, Miika T.
通讯作者：
Nieminen, Miika T.
DOI：
10.1038/bonekey.2014.59
发表时间：
2014-01-01
期刊：
BoneKEy reports
影响因子：
--
作者：
Campbell, Graeme M;Sophocleous, Antonia
通讯作者：
Sophocleous, Antonia
影响因子：
--
作者：
Garwood, Michael;Idiyatullin, Djaudat;Nixdorf, Donald R.
通讯作者：
Nixdorf, Donald R.
影响因子：
4.2
作者：
Idiyatullin, Djaudat;Corum, Curt;Nixdorf, Donald R.
通讯作者：
Nixdorf, Donald R.