D₁ receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test.
D₁ receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test.
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DOI：
10.1007/s00213-011-2460-8
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发表时间：
2012-03
影响因子：
3.4
通讯作者：
Neill JC
中科院分区：
文献类型：
--
作者：
Barnes SA;Young JW;Neill JC
注意力/警惕性受损被认为是精神分裂症的核心。据报道，多巴胺能 D1 受体系统是改善精神分裂症患者认知的最有希望的靶点之一，一些证据表明 D1 激活可能会改善持续注意力。这项研究的目的有两个：首先评估使用大鼠进行五项选择连续性能测试 (5C-CPT) 的适用性，该测试最近在小鼠中进行了验证。其次，研究了 D1 部分激动剂 SKF 38393 的全身给药对基线期间任务表现的影响，以及由降低事件率组成的挑战课程。 ：训练动物执行 5C-CPT，并在全身 SKF 38393（2、4 和 6 mg/kg）与载体给药后评估性能。大鼠可以区分 5C-CPT 中的目标（需要响应）和非目标（需要抑制响应）试验。此外，SKF 38393 治疗会损害基线会话期间的性能，减少目标检测，但在减少事件率挑战会话期间提高性能，增加目标检测并改善信号辨别力，表明 SKF 38393 引起的警惕性增强。因此，这些数据表明 D1 系统的激活以基线依赖性方式影响 5C-CPT 性能。可以训练大鼠执行 5C-CPT，适当地抑制对非目标试验的反应。全身施用 SKF 38393 会损害基线条件下的性能。在完成与任务相关的挑战后，事件发生率降低，多巴胺 (DA) D1 系统的激活通过提高动物的警惕水平来提高表现，并使用信号检测理论进行量化。
Impaired attention/vigilance is putatively core to schizophrenia. The dopaminergic D1 receptor system has been reported as one of the most promising targets for improving cognition in patients with schizophrenia, with some evidence suggesting D1 activation may improve sustained attention. The purpose of this study was twofold: firstly assessing the applicability of using rats in the 5-Choice Continuous Performance Test (5C-CPT), recently validated in mice. Secondly, the effect of systemic administration of a D1 partial agonist, SKF 38393, on task performance during baseline, and a challenge session consisting of a reduced event-rate was investigated. : Animals were trained to perform the 5C-CPT with performance assessed following systemic SKF 38393 (2, 4 and 6 mg/kg) vs. vehicle administration. Rats could discriminate between target (requiring a response) and non-target (requiring the inhibition of response) trials within the 5C-CPT. Moreover, SKF 38393 treatment impaired performance during the baseline session reducing target detection, yet improved performance during the reduced event-rate challenge session, increasing target detection and improving signal discrimination indicating an SKF 38393-induced enhancement of vigilance. Thus, these data suggest that activation of the D1 system affected 5C-CPT performance in a baseline dependent manner. Rats can be trained to perform the 5C-CPT, appropriately withholding from responding to non-target trials. Systemic administration of SKF 38393 impaired performance during baseline conditions. Following a task-related challenge, which reduced the event rate, activation of the dopamine (DA) D1 system improved performance by heightening the animals’ vigilance levels, quantified using signal detection theory.
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影响因子：
2.7
作者：
CARLI, M;ROBBINS, TW;EVERITT, BJ
通讯作者：
EVERITT, BJ
影响因子：
3.4
作者：
DUDCHENKO, P;PAUL, B;SARTER, M
通讯作者：
SARTER, M
DOI：
10.1023/a:1023525007441
发表时间：
2003-09-01
影响因子：
1.6
作者：
Collings, RD
通讯作者：
Collings, RD
影响因子：
3.3
作者：
HERSI, AI;ROWE, W;QUIRION, R
通讯作者：
QUIRION, R
影响因子：
2.4
作者：
LAM, CM;BEALE, IL
通讯作者：
BEALE, IL