Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight.
Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight.
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DOI：
10.1289/ehp.1104615
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发表时间：
2012-07
影响因子：
10.4
通讯作者：
Lanphear BP
中科院分区：
文献类型：
--
作者：
Rauch SA;Braun JM;Barr DB;Calafat AM;Khoury J;Montesano AM;Yolton K;Lanphear BP
背景：出生前接触有机磷(OP)杀虫剂，这是一种广泛使用的杀虫剂，可能与降低胎龄和出生体重有关。对氧磷酶(PON1)酶基因的单核苷酸多态可能改变OP暴露与围产儿结局之间的关系。目的：通过尿二烷基磷酸(DAP)代谢产物浓度测定，探讨孕期有机磷农药暴露与胎龄和出生体重的关系。方法：我们测定了6种OP类杀虫剂的非特异性DAP代谢物在两名孕妇现场尿样中的浓度。我们进行了多变量回归，以检验六种二氨基苯酚浓度之和(Σ，二氨基苯酚)与胎龄和出生体重之间的关系。我们还检查了这些关联是否根据婴儿PON1192和PON1-108基因类型的不同而不同。结果：在306名母婴中，Σ-DAP浓度增加10倍与调整后胎龄[-0.5周；95%可信区间(CI)：-0.8，-0.1]和出生体重(-151g；CI：-287，-16)的下降有关；调整胎龄后，出生体重的下降有所减弱。白人(-0.7周；CI：-1.1，-0.3)新生儿ΣDAP浓度与胎龄的关系比黑人(-0.1周；95%CI：-0.9，0.6)强。相反，黑人新生儿(-188g；CI：-395，19)的出生体重下降幅度大于白人(-118g；CI：-296，60)新生儿的尿中ΣDAP浓度。在携带PON1192QR和Σ-108CT基因的婴儿中，出生体重和胎龄的下降与PON1192QR和PON-108CT的DAP浓度相关最大。结论：在该队列中，产前尿PON1192/108DAP浓度与妊娠缩短和出生体重降低有关，但其影响因种族和Σ1192/108型而不同。
Background: Prenatal exposure to organophosphate (OP) insecticides, a widely used class of pesticides, may be associated with decreased gestational age and lower birth weight. Single nucleotide polymorphisms in paroxanase (PON1) enzyme genotypes may modify the relationships between OP exposure and perinatal outcomes. Objective: We examined the relationship of prenatal OP insecticide exposure, measured using urinary dialkyl phosphate (DAP) metabolite concentrations, with gestational age and birth weight. Methods: We measured the concentrations of six nonspecific DAP metabolites of OP insecticides in two maternal spot urine samples collected in a prospective birth cohort. We performed multivariable regression to examine associations between the sum of six DAP concentrations (ΣDAP) with gestational age and birth weight. We also examined whether these associations differed according to infant PON1192 and PON1–108 genotypes. Results: Among 306 mother–infant dyads, a 10-fold increase in ΣDAP concentrations was associated with a decrease in covariate-adjusted gestational age [–0.5 weeks; 95% confidence interval (CI): –0.8, –0.1] and birth weight (–151 g; CI: –287, –16); the decrements in birth weight were attenuated after adjusting for gestational age. The relationship between ΣDAP concentrations and gestational age was stronger for white (–0.7 weeks; CI: –1.1, –0.3) than for black (–0.1 weeks; 95% CI: –0.9, 0.6) newborns. In contrast, there was a greater decrease in birth weight with increasing urinary ΣDAP concentrations for black (–188 g; CI: –395, 19) than for white (–118 g; CI: –296, 60) newborns. Decrements in birth weight and gestational age associated with ΣDAP concentrations were greatest among infants with PON1192QR and PON–108CT genotypes. Conclusions: Prenatal urinary ΣDAP concentrations were associated with shortened gestation and reduced birth weight in this cohort, but the effects differed by race/ethnicity and PON1192/108 genotypes.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
10.4
作者：
Gee, Gilbert C;Payne-Sturges, Devon C
通讯作者：
Payne-Sturges, Devon C
影响因子：
2.8
作者：
Lynch, Courtney D.;Zhang, Jun
通讯作者：
Zhang, Jun
DOI：
10.1038/sj.jea.7500322
发表时间：
2004-05-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Bravo, R;Caltabiano, LM;Barr, DB
通讯作者：
Barr, DB
DOI：
10.1080/15287390590890554
发表时间：
2005-02-13
影响因子：
2.6
作者：
Lu, C;Bravo, R;Barr, DB
通讯作者：
Barr, DB