Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19.
Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19.
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DOI：
10.1016/j.jcv.2021.104847
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Kühn J
中科院分区：
文献类型：
--
作者：
Dugas M;Grote-Westrick T;Merle U;Fontenay M;Kremer AE;Hanses F;Vollenberg R;Lorentzen E;Tiwari-Heckler S;Duchemin J;Ellouze S;Vetter M;Fürst J;Schuster P;Brix T;Denkinger CM;Müller-Tidow C;Schmidt H;Tepasse PR;Kühn J
绝大多数COVID-19患者的病情较轻。然而，少数人患有严重疾病，发病率和死亡率很高。为了识别处于严重COVID-19风险中的个体，分析了针对季节性人类冠状病毒的血清反应性的相关性。我们进行了一项多中心非干预性研究，包括来自德国和法国四个三级护理转诊中心的296例确诊SARS-CoV-2感染的患者。重症监护组的男性较多，而门诊组的女性比例较高。对于每例患者，通过免疫印迹法检查症状发作后最接近的血清或血浆样本中针对HCoV 229 E、NL 63、OC 43和HKU 1的核衣壳蛋白（NP）的IgG抗体。中位年龄为60岁（范围18-96岁）。与其他COVID-19住院患者相比，重症患者（n=106）的抗HCoV OC 43核衣壳蛋白（NP）特异性抗体水平显著较低（p=0.007）。在多因素分析中（校正了年龄、性别和BMI），OC 43阴性的住院患者发生危重病的风险增加（校正的比值比（AOR）2.68 [95%CI 1.09 - 7.05]），高于年龄或BMI增加的风险，低于男性的风险。基于性别和OC 43血清状态的风险分层来自该分析。我们的研究结果表明，先前感染季节性人类冠状病毒可以预防严重的COVID-19病程。因此，应测量COVID-19住院患者的抗OC 43抗体，并将其视为每位患者风险评估的一部分。因此，我们预计抗OC 43抗体检测阴性的个体特别受益于SARS-CoV-2疫苗接种，特别是在其他风险因素占主导地位的情况下。
The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. To identify individuals at risk of critical COVID-19, the relevance of a seroreactivity against seasonal human coronaviruses was analyzed. We conducted a multi-center non-interventional study comprising 296 patients with confirmed SARS-CoV-2 infections from four tertiary care referral centers in Germany and France. The ICU group comprised more males, whereas the outpatient group contained a higher percentage of females. For each patient, the serum or plasma sample obtained closest after symptom onset was examined by immunoblot regarding IgG antibodies against the nucleocapsid protein (NP) of HCoV 229E, NL63, OC43 and HKU1. Median age was 60 years (range 18-96). Patients with critical disease (n=106) had significantly lower levels of anti-HCoV OC43 nucleocapsid protein (NP)-specific antibodies compared to other COVID-19 inpatients (p=0.007). In multivariate analysis (adjusted for age, sex and BMI), OC43 negative inpatients had an increased risk of critical disease (adjusted odds ratio (AOR) 2.68 [95% CI 1.09 - 7.05]), higher than the risk by increased age or BMI, and lower than the risk by male sex. A risk stratification based on sex and OC43 serostatus was derived from this analysis. Our results suggest that prior infections with seasonal human coronaviruses can protect against a severe course of COVID-19. Therefore, anti-OC43 antibodies should be measured for COVID-19 inpatients and considered as part of the risk assessment for each patient. Hence, we expect individuals tested negative for anti-OC43 antibodies to particularly benefit from vaccination against SARS-CoV-2, especially with other risk factors prevailing.
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影响因子：
56.9
作者：
Kissler, Stephen M.;Tedijanto, Christine;Lipsitch, Marc
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.ijid.2020.09.003
发表时间：
2020-11
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Dugas M;Schrempf IM;Ochs K;Frömmel C;Greulich L;Neuhaus P;Tepasse PR;Schmidt HH
通讯作者：
Schmidt HH
影响因子：
64.8
作者：
Le Bert, Nina;Tan, Anthony T.;Bertoletti, Antonio
通讯作者：
Bertoletti, Antonio