Regeneration of the periodontium using enamel matrix derivative in combination with an injectable bone cement.
Regeneration of the periodontium using enamel matrix derivative in combination with an injectable bone cement.
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DOI：
10.1007/s00784-012-0743-z
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发表时间：
2013-03
影响因子：
3.4
通讯作者：
Jansen, John A.
中科院分区：
文献类型：
--
作者：
Oortgiesen, Daniel A. W.;Meijer, Gert J.;Bronckers, Antonius L. J. J.;Walboomers, X. Frank;Jansen, John A.
牙釉质基质衍生物（EMD）已被证明可以增强牙周再生；然而，其作用主要限于软牙周组织。因此，为了不仅刺激软组织，而且刺激硬组织，在本研究中，EMD 与可注射磷酸钙水泥（CaP；骨移植材料）相结合。目的是从组织学角度评估大孔 CaP 与 EMD 结合的愈合情况。在 15 只大鼠的第一上磨牙近中处创建骨内三壁牙周缺损（2 × 2 × 1.7 mm）（30 个缺损）。根据以下三种策略之一随机处理缺陷：EMD、磷酸钙水泥和 EMD，或留空。 12 周后处死动物，并对回收的样本进行组织学和组织形态计量学处理。空缺损表现为修复性愈合，没有牙周膜或骨再生。根据牙周再生的组织学分级量表进行测量，实验组（EMD 和 CaP/EMD）得分相同，均比空缺损高出三倍。然而，大多数骨形成是在 CaP/EMD 组中测量的；与单独使用 EMD 相比，在 EMD 中添加 CAP 显着增强了骨形成 50%。在这项动物研究的范围内，辅助使用 EMD 与可注射水泥相结合，尽管它不影响上皮向下生长，但似乎是牙周组织中骨和韧带组织再生的一种有前途的治疗方式。 EMD 与可注射水泥的辅助使用似乎是牙周组织中骨和韧带组织再生的一种有前途的治疗方式。
Enamel matrix derivative (EMD) has proven to enhance periodontal regeneration; however, its effect is mainly restricted to the soft periodontal tissues. Therefore, to stimulate not only the soft tissues, but also the hard tissues, in this study EMD is combined with an injectable calcium phosphate cement (CaP; bone graft material). The aim was to evaluate histologically the healing of a macroporous CaP in combination with EMD. Intrabony, three-wall periodontal defects (2 × 2 × 1.7 mm) were created mesial of the first upper molar in 15 rats (30 defects). Defects were randomly treated according to one of the three following strategies: EMD, calcium phosphate cement and EMD, or left empty. The animals were killed after 12 weeks, and retrieved samples were processed for histology and histomorphometry. Empty defects showed a reparative type of healing without periodontal ligament or bone regeneration. As measured with on a histological grading scale for periodontal regeneration, the experimental groups (EMD and CaP/EMD) scored equally, both threefold higher compared with empty defects. However, most bone formation was measured in the CaP/EMD group; addition of CAP to EMD significantly enhanced bone formation with 50 % compared with EMD alone. Within the limits of this animal study, the adjunctive use of EMD in combination with an injectable cement, although it did not affect epithelial downgrowth, appeared to be a promising treatment modality for regeneration of bone and ligament tissues in the periodontium. The adjunctive use of EMD in combination with an injectable cement appears to be a promising treatment modality for regeneration of the bone and ligament tissues in the periodontium.
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DOI：
10.1163/156856206778366004
发表时间：
2006-01-01
影响因子：
3.6
作者：
Habraken, W. J. E. M.;Wolke, J. G. C.;Jansen, J. A.
通讯作者：
Jansen, J. A.
影响因子：
14
作者：
JANSEN, JA;DERUIJTER, JE;PAQUAY, YGGJ
通讯作者：
PAQUAY, YGGJ
影响因子：
4.3
作者：
Nemcovsky, Carlos E.;Zahavi, Shira;Weinreb, Miron
通讯作者：
Weinreb, Miron
影响因子：
4.3
作者：
Shirakata, Y;Oda, S;Ishikawa, I
通讯作者：
Ishikawa, I
DOI：
10.3109/08941939409015356
发表时间：
1994-03-01
期刊：
Journal of investigative surgery : the official journal of the Academy of Surgical Research
影响因子：
--
作者：
Jansen, J A;Dhert, W J;von Recum, A F
通讯作者：
von Recum, A F