Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle.
Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle.
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多策略全基因组关联研究确定 DCAF16-NCAPG 区域是牛平均日增重的易感位点
DOI：
10.1038/srep38073
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发表时间：
2016-11-28
影响因子：
4.6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Zhang W;Li J;Guo Y;Zhang L;Xu L;Gao X;Zhu B;Gao H;Ni H;Chen Y
Average daily gain (ADG) is the most economically important trait in beef cattle industry. Using genome-wide association study (GWAS) approaches, previous studies have identified several causal variants within thePLAG1, NCAPGandLCORLgenes for ADG in cattle. Multi-strategy GWASs were implemented in this study to improve detection and to explore the causal genes and regions. In this study, we conducted GWASs based on the genotypes of 1,173 Simmental cattle. In the SNP-based GWAS, the most significant SNPs (rs109303784 and rs110058857, P = 1.78 × 10−7) were identified in theNCAPGintron on BTA6 and explained 4.01% of the phenotypic variance, and the independent and significant SNP (rs110406669, P = 5.18 × 10−6) explained 3.32% of the phenotypic variance. Similarly, in the haplotype-based GWAS, the most significant haplotype block, Hap-6-N1416 (P = 2.56 × 10−8), spanned 12.7 kb on BTA6 and explained 4.85% of the phenotypic variance. Also, in the gene-based GWAS, seven significant genes were obtained which includedDCAF16andNCAPG. Moreover, analysis of the transcript levels confirmed that transcripts abundance ofNCAPG(P = 0.046) andDCAF16(P = 0.046) were significantly correlated with the ADG trait. Overall, our results from the multi-strategy GWASs revealed theDCAF16-NCAPGregion to be a susceptibility locus for ADG in cattle.
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影响因子：
4.4
作者：
Boyko AR;Brooks SA;Behan-Braman A;Castelhano M;Corey E;Oliveira KC;Swinburne JE;Todhunter RJ;Zhang Z;Ainsworth DM;Robinson NE
通讯作者：
Robinson NE
影响因子：
3.3
作者：
Browning BL;Browning SR
通讯作者：
Browning SR
影响因子：
4.4
作者：
Gregersen VR;Conley LN;Sørensen KK;Guldbrandtsen B;Velander IH;Bendixen C
通讯作者：
Bendixen C
基于基因的全基因组关联研究鉴定出多发性硬化症的易感基因
DOI：
10.3988/jcn.2015.11.4.311
发表时间：
2015-10
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Lin X;Deng FY;Lu X;Lei SF
通讯作者：
Lei SF
影响因子：
2.6
作者：
Kang, Guolian;Jiang, Bo;Cui, Yuehua
通讯作者：
Cui, Yuehua