Fibrocytes: emerging effector cells in chronic inflammation.
Fibrocytes: emerging effector cells in chronic inflammation.
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DOI：
10.1038/nri2990
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发表时间：
2011-06
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影响因子：
--
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纤维细胞是由单核细胞前体产生的间充质细胞。它们存在于受损器官中，具有巨噬细胞的炎症特征和成纤维细胞的组织重塑特性。慢性炎症刺激介导这些细胞在与自身免疫、心血管疾病和哮喘相关的纤维化条件下的分化、运输和积累。本文讨论了控制纤维细胞分化和募集的免疫介质，描述了纤维细胞与慢性炎性疾病的关联，并比较了纤维细胞与巨噬细胞和成纤维细胞在这些疾病中的潜在作用。希望这一信息能为研究这些独特的细胞提供新的机会。
Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in injured organs and have both the inflammatory features of macrophages and the tissue remodelling properties of fibroblasts. Chronic inflammatory stimuli mediate the differentiation, trafficking and accumulation of these cells in fibrosing conditions associated with autoimmunity, cardiovascular disease and asthma. This Opinion article discusses the immunological mediators controlling fibrocyte differentiation and recruitment, describes the association of fibrocytes with chronic inflammatory diseases and compares the potential roles of fibrocytes in these disorders with those of macrophages and fibroblasts. It is hoped that this information prompts new opportunities for the study of these unique cells.
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DOI：
10.1161/atvbaha.110.209692
发表时间：
2010-10-01
影响因子：
8.7
作者：
Daniel, Jan-Marcus;Bielenberg, Wiebke;Sedding, Daniel G.
通讯作者：
Sedding, Daniel G.
影响因子：
3.5
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影响因子：
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通讯作者：
Salmon M
DOI：
10.1073/pnas.94.12.6307
发表时间：
1997-06-10
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
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