Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications.
Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications.
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DOI：
10.1039/c8ra02912a
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发表时间：
2018-05-25
期刊：
影响因子：
3.9
通讯作者：
Luo, Jianbin
中科院分区：
文献类型：
--
作者：
Meng, Fancui;Qiao, Zhuangzhuang;Yao, Yan;Luo, Jianbin
为了进一步提高聚氨酯软段上叠氮基的含量，提高叠氮基在聚氨酯表面的富集程度，以便于进一步功能化，制备了软段上具有叠氮基的聚氨酯（PU-GAP）。用叠氮化钠将聚环氧氯丙烷（PECH）上的氯侧基转化为叠氮基，制备了含叠氮侧基的聚合物二元醇（GAP）。用GPC、1H NMR和FTIR对所制备的PECH、GAP和PU-GAP进行了表征。以炔丙基mPEG（mPEG-炔）为模型表面改性剂，通过点击化学法将其接枝到所制备的含叠氮基聚氨酯膜上。采用SEM、XPS和水接触角分析等方法研究了复合材料的表面形貌、化学组成和润湿性。SEM结果表明，mPEG改性后的PU表面与原始PU表面具有不同的表面拓扑结构。XPS和WCA分析证明mPEG成功地接枝到PU的侧链叠氮基团上。mPEG改性的PU表面表现出良好的抗菌活性，分子量较大的mPEG改性的PU表面表现出更好的抗细菌附着效率。因此，我们制备的表面反应型聚氨酯可以作为一个通用的平台，进一步功能化根据实际应用。软段上具有侧链叠氮基团的聚氨酯，其可以根据实际应用成为进一步官能化的通用平台。
Polyurethane with pendant azide groups on the soft segment (PU-GAP) was prepared in this study to further increase the content of reactive azide groups and improve their surfaces enrichment for further functionalization. Polymer diols with pendant azide groups (GAP) were prepared by transforming the pendant chlorine groups at polyepichlorohydrin (PECH) into azide groups with sodium azide. The prepared PECH, GAP and PU-GAP was characterized by GPC, 1H NMR and FTIR. Propargylic mPEG (mPEG-alkyne) was used as model surface modification reagents which was grafted on the prepared azido containing polyurethane films via click chemistry. The surface morphology, chemical composition and wettabilities were studied by SEM, XPS and water contact angle (WCA) analysis, respectively. SEM results demonstrated different surface topologies between mPEG modified PU surface and original PU surface. XPS and WCA analysis proved the successful grafting of mPEG on the pendant azide groups of PUs. The mPEG modified PU surfaces demonstrated good antifouling activities against model bacteria and mPEG with larger molecular weights modified surfaces showed better resistance efficiency to attachment of bacteria. Therefore, the surface reactive polyurethane we prepared can be a universal platform for further functionalization according actual applications. Polyurethane with pendant azide groups on the soft segment which can be an universal platform for further functionalization according actual applications.
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