Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes.
Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes.
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DOI：
10.1007/s00018-014-1739-4
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发表时间：
2015-01
影响因子：
8
通讯作者：
Wang, Qiang
中科院分区：
文献类型：
--
作者：
Gu, Ling;Liu, Honglin;Gu, Xi;Boots, Christina;Moley, Kelle H.;Wang, Qiang
肥胖、糖尿病及相关代谢紊乱是世界范围内的主要健康问题。随着代谢紊乱的流行，相关的医疗合并症，包括对生殖的有害影响，也在增加。新出现的证据表明，母体营养对生殖结果的影响可能至少部分是由卵母细胞代谢介导的。平衡和定时的能量代谢对卵母细胞的最佳发育至关重要。迄今为止，我们对卵母细胞代谢的理解大多来自于外来营养物质对卵母细胞成熟的影响。相比之下，卵母细胞发育的内在调节由代谢酶、细胞内介质和运输系统较少表征。具体来说，卵母细胞中酸转运蛋白水平的降低、葡萄糖/脂质含量的增加和活性氧含量的升高与减数分裂缺陷、细胞器功能障碍和表观遗传改变有关。因此，卵母细胞代谢紊乱可能导致代谢紊乱的女性生殖潜力下降。需要深入研究以进一步探索其潜在机制。本文还讨论了几种代谢分析方法。卵母细胞、周围颗粒细胞和卵泡液的代谢组学分析将揭示调节卵母细胞发育的代谢网络，可能导致鉴定卵母细胞质量标记和预防生殖疾病和后代的不良结局。
Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As the epidemic of metabolic disorders continues, the associated medical comorbidities, including the detrimental impact on reproduction, increase as well. Emerging evidence suggests that the effects of maternal nutrition on reproductive outcomes are likely to be mediated, at least in part, by oocyte metabolism. Well-balanced and timed energy metabolism is critical for optimal development of oocytes. To date, much of our understanding of oocyte metabolism comes from the effects of extrinsic nutrients on oocyte maturation. In contrast, intrinsic regulation of oocyte development by metabolic enzymes, intracellular mediators, and transport systems is less characterized. Specifically, decreased acid transport proteins levels, increased glucose/lipid content and elevated reactive oxygen species in oocytes have been implicated in meiotic defects, organelle dysfunction and epigenetic alteration. Therefore, metabolic disturbances in oocytes may contribute to the diminished reproductive potential experienced by women with metabolic disorders. In-depth research is needed to further explore the underlying mechanisms. This review also discusses several approaches for metabolic analysis. Metabolomic profiling of oocytes, the surrounding granulosa cells, and follicular fluid will uncover the metabolic networks regulating oocyte development, potentially leading to the identification of oocyte quality markers and prevention of reproductive disease and poor outcomes in offspring.
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DOI：
10.1186/1477-7827-10-49
发表时间：
2012-06-29
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
通讯作者：
Gupta S
影响因子：
2.5
作者：
Augustin, R;Pocar, P;Fischer, B
通讯作者：
Fischer, B
影响因子：
6.7
作者：
Bellver, J;Rossal, LP;Pellicer, A
通讯作者：
Pellicer, A
影响因子：
13.3
作者：
Anckaert, Ellen;De Rycke, Martine;Smitz, Johan
通讯作者：
Smitz, Johan
影响因子：
6.7
作者：
Bellver, Jose;Melo, Marco A. B.;Pellicer, Antonio
通讯作者：
Pellicer, Antonio