New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
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在发育和成年海马形成过程中，闪光蛋白3E及其受体Plexind1的新功能。
DOI：
10.1038/s41598-018-19794-0
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发表时间：
2018-01-22
影响因子：
4.6
通讯作者：
Del Río JA
中科院分区：
文献类型：
--
作者：
Mata A;Gil V;Pérez-Clausell J;Dasilva M;González-Calixto MC;Soriano E;García-Verdugo JM;Sanchez-Vives MV;Del Río JA
皮层神经回路的发育和成熟依赖于长距离和短距离轴突引导信号的协调作用。在这方面，3类脑信号蛋白及其受体已被视为参与海马连接的发育和成熟。然而，虽然他们的大部分家庭成员的作用已被描述，非常少的数据参与Semaphorin 3E（Sema 3E）和它的受体丛蛋白D1在发育和成熟的内鼻-海马（EH）连接。在本研究中，我们专注于确定他们在发育和成年期间的角色。我们确定了Sema 3E/丛蛋白D1在EH连接的层特异性发展中的相关作用。事实上，缺乏Sema 3E/PlexinD 1信号的小鼠在胚胎和围产期阶段表现出海马内嗅轴突的异常分层。此外，Sema 3E/丛蛋白D1信号的缺乏导致出生后和成年海马结构的进一步变化，例如许多错误路由的异位苔藓纤维。更相关的是，我们描述了颗粒下细胞如何表达丛蛋白D1，以及Sema 3E的缺乏如何诱导齿状回祖细胞增殖失调，导致分子层中存在异位细胞。最后，Sema 3E突变小鼠在齿状回和海马中表现出增加的网络兴奋性。
The development and maturation of cortical circuits relies on the coordinated actions of long and short range axonal guidance cues. In this regard, the class 3 semaphorins and their receptors have been seen to be involved in the development and maturation of the hippocampal connections. However, although the role of most of their family members have been described, very few data about the participation of Semaphorin 3E (Sema3E) and its receptor PlexinD1 during the development and maturation of the entorhino-hippocampal (EH) connection are available. In the present study, we focused on determining their roles both during development and in adulthood. We determined a relevant role for Sema3E/PlexinD1 in the layer-specific development of the EH connection. Indeed, mice lacking Sema3E/PlexinD1 signalling showed aberrant layering of entorhinal axons in the hippocampus during embryonic and perinatal stages. In addition, absence of Sema3E/PlexinD1 signalling results in further changes in postnatal and adult hippocampal formation, such as numerous misrouted ectopic mossy fibers. More relevantly, we describe how subgranular cells express PlexinD1 and how the absence of Sema3E induces a dysregulation of the proliferation of dentate gyrus progenitors leading to the presence of ectopic cells in the molecular layer. Lastly, Sema3E mutant mice displayed increased network excitability both in the dentate gyrus and the hippocampus proper.
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影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
16.2
作者：
Bellon, Anais;Luchino, Jonathan;Mann, Fanny
通讯作者：
Mann, Fanny
影响因子：
16.2
作者：
Chen, H;Bagri, A;Tessier-Lavigne, M
通讯作者：
Tessier-Lavigne, M
影响因子：
5.3
作者：
Davies, SJA;Field, PM;Raisman, G
通讯作者：
Raisman, G
影响因子：
5.5
作者：
Contreras, D;Timofeev, I;Steriade, M
通讯作者：
Steriade, M