Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.
Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.
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DOI：
10.1016/j.autneu.2022.102967
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Grippo AJ
中科院分区：
文献类型：
--
作者：
Watanasriyakul WT;Scotti ML;Carter CS;McNeal N;Colburn W;Wardwell J;Grippo AJ
社会孤立影响抑郁和焦虑相关的疾病和心脏功能的改变。催产素可能通过中枢和/或外周机制，通过与社会行为、情感和心血管功能的相互作用来调节这些情况。本研究利用L-368,899（一种通过血脑屏障的选择性催产素受体拮抗剂）研究了催产素拮抗剂对草原田鼠抑郁和焦虑相关行为和心率的影响。这种啮齿类动物在研究社会压力、行为、心脏反应和催产素功能的相互作用方面具有翻译价值。成年雌性草原田鼠被社会隔离或与兄弟姐妹合住4周。在每种饲养条件下，选取一部分动物进行4次急性L-368,899 （20 mg/kg, ip）或生理盐水给药，然后进行抑郁或焦虑相关行为评估。在急性给药L-368,899 （20 mg/kg, ip）和行为评估期间，对一组共饲养动物的心功能进行了评估。社会隔离（与共同居住相比）增加了与抑郁和焦虑相关的行为。在孤立动物中，L-368,899对焦虑相关行为没有影响，但加重了抑郁相关行为。在同住的动物中，L-368,899加重了与抑郁相关的行为，并在基线和行为测试期间增加了心率。草原田鼠的社会孤立会产生与情绪相关的行为；中枢和/或外周催产素拮抗剂加剧了这些行为迹象。催产素拮抗剂诱导共住草原田鼠的抑郁相关行为，并增加基础心率和应激反应心率，类似于本模型中显示的社会隔离的后果。这些结果为那些因孤独或社会压力而经历行为和心脏后果的人提供了翻译价值。
Social isolation influences depression- and anxiety-related disorders and altered cardiac function. Oxytocin may mediate these conditions through interactions with social behavior, emotion, and cardiovascular function, via central and/or peripheral mechanisms. The present study investigated the influence of oxytocin antagonism using L-368,899, a selective oxytocin receptor antagonist that crosses the blood-brain barrier, on depression- and anxiety-related behaviors and heart rate in prairie voles. This rodent species has translational value for investigating interactions of social stress, behavior, cardiac responses, and oxytocin function. Adult female prairie voles were socially isolated or co-housed with a sibling for 4 weeks. A subset of animals in each housing condition was subjected to 4 sessions of acute L-368,899 (20 mg/kg, ip) or saline administration followed by a depression- or anxiety-related behavioral assessment. A subset of co-housed animals was evaluated for cardiac function following acute administration of L-368,899 (20 mg/kg, ip) and during behavioral assessments. Social isolation (vs. co-housing) increased depression- and anxiety-related behaviors. In isolated animals, L-368,899 (vs. vehicle) did not influence anxiety-related behaviors but exacerbated depression-related behaviors. In co-housed animals, L-368,899 exacerbated depression-related behaviors and increased heart rate at baseline and during behavioral tests. Social isolation produces emotion-related behaviors in prairie voles; central and/or peripheral oxytocin antagonism exacerbates these behavioral signs. Oxytocin antagonism induces depression-relevant behaviors and increases basal and stressor-reactive heart rate in co-housed prairie voles, similar to the consequences of social isolation demonstrated in this model. These results provide translational value for humans who experience behavioral and cardiac consequences of loneliness or social stress.
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