The neuroendocrinology of social isolation.
The neuroendocrinology of social isolation.
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DOI：
10.1146/annurev-psych-010814-015240
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发表时间：
2015-01-03
影响因子：
24.8
通讯作者：
Cole SW
中科院分区：
文献类型：
--
作者：
Cacioppo JT;Cacioppo S;Capitanio JP;Cole SW
世纪以来，社会隔离一直被认为是人类发病率和死亡率的主要风险因素。虽然研究的重点一直是客观的社会角色和健康行为，但大脑是形成、监测、维持、修复和取代与他人有益联系的关键器官。因此，基于人群的纵向研究表明，感知的社会隔离（孤独）是独立于客观社会隔离和健康行为的发病率和死亡率的危险因素。对可能涉及的神经内分泌应激机制进行的人类和动物研究表明：（a）长期社会隔离增加了下丘脑垂体肾上腺皮质轴的激活，（B）这些影响更多地依赖于重要配对之间社会纽带的破坏，而不是客观隔离本身。相关因素和神经内分泌，神经生物学和遗传机制，可能有助于感知隔离和死亡率之间的关联进行了审查。
Social isolation has been recognized as a major risk factor for morbidity and mortality in humans for more than a quarter of a century. Although the focus of research has been on objective social roles and health behavior, the brain is the key organ for forming, monitoring, maintaining, repairing, and replacing salutary connections with others. Accordingly, population-based longitudinal research indicates that perceived social isolation (loneliness) is a risk factor for morbidity and mortality independent of objective social isolation and health behavior. Human and animal investigations of neuroendocrine stress mechanisms that may be involved suggest that (a) chronic social isolation increases the activation of the hypothalamic pituitary adrenocortical axis, and (b) these effects are more dependent on the disruption of a social bond between a significant pair than objective isolation per se. The relational factors and neuroendocrine, neurobiological, and genetic mechanisms that may contribute to the association between perceived isolation and mortality are reviewed.
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影响因子：
7.2
作者：
Cacioppo, JT;Hawkey, LC;Berntson, GG
通讯作者：
Berntson, GG
影响因子：
2.9
作者：
CARBONARO, DA;FRIEND, TH;NUTI, LC
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NUTI, LC
影响因子：
3.3
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Cacioppo, JT;Hawkley, LC;Berntson, GG
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Berntson, GG
影响因子：
19.9
作者：
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Hawkey, Louise C.
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Cacioppo, Stephanie;Frum, Chris;Asp, Erik;Weiss, Robin M.;Lewis, James W.;Cacioppo, John T.
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