Age-related changes in circadian regulation of the human plasma lipidome.
Age-related changes in circadian regulation of the human plasma lipidome.
复制标题
人类血浆脂质组的昼夜节律调节与年龄相关的变化。
DOI：
10.1038/s42003-023-05102-8
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发表时间：
2023-07-20
影响因子：
5.9
通讯作者：
Kristal, Bruce S.
中科院分区：
文献类型：
--
作者：
Rahman, Shadab A.;Gathungu, Rose M.;Marur, Vasant R.;St. Hilaire, Melissa A.;Scheuermaier, Karine;Belenky, Marina;Struble, Jackson S.;Czeisler, Charles A.;Lockley, Steven W.;Klerman, Elizabeth B.;Duffy, Jeanne F.;Kristal, Bruce S.
衰老改变了中枢调节的昼夜节律的幅度和相位。在此，我们通过回顾性的脂质组学分析，对24名健康个体的血浆样本进行了评估，以确定血浆脂质组的外周昼夜节律是否会因衰老而改变（9例女性;平均值± SD年龄：40.9 ± 18.2岁），包括12名年轻人（4名女性，23.5 ± 3.9岁）和12名中年以上，（5名女性，58.3 ± 4.2岁）个体，在27小时恒定常规（CR）方案中每3小时进行一次，该方案允许将诱发变化与生理学中内源性产生的振荡分离。余弦回归显示两组中25%的脂质具有昼夜节律性。平均而言，老年组脂质昼夜节律的振幅降低约14%，峰值相提前约2.1小时（两者均为p ≤ 0.001）。此外，与年轻组（18/58，p < 0.0001）相比，老年组（44/56）中除了27小时CR的正弦曲线外，更多节律性昼夜节律脂质具有显著的线性成分。个体水平数据的结果与组平均结果一致。结果表明，人类血浆脂质体的内源性昼夜节律的患病率与健康的老龄化到中年，但节奏的显着变化，包括幅度减少，早期acrophase，和改变中央和脂质节律之间的时间关系。人血浆脂质组中的固有昼夜节律在健康老龄化过程中得以保留，但与年轻成人相比，老年人的昼夜节律脂质谱的相位和振幅显著提前。
Aging alters the amplitude and phase of centrally regulated circadian rhythms. Here we evaluate whether peripheral circadian rhythmicity in the plasma lipidome is altered by aging through retrospective lipidomics analysis on plasma samples collected in 24 healthy individuals (9 females; mean ± SD age: 40.9 ± 18.2 years) including 12 younger (4 females, 23.5 ± 3.9 years) and 12 middle-aged older, (5 females, 58.3 ± 4.2 years) individuals every 3 h throughout a 27-h constant routine (CR) protocol, which allows separating evoked changes from endogenously generated oscillations in physiology. Cosinor regression shows circadian rhythmicity in 25% of lipids in both groups. On average, the older group has a ~14% lower amplitude and a ~2.1 h earlier acrophase of the lipid circadian rhythms (both, p ≤ 0.001). Additionally, more rhythmic circadian lipids have a significant linear component in addition to the sinusoidal across the 27-h CR in the older group (44/56) compared to the younger group (18/58, p < 0.0001). Results from individual-level data are consistent with group-average results. Results indicate that prevalence of endogenous circadian rhythms of the human plasma lipidome is preserved with healthy aging into middle-age, but significant changes in rhythmicity include a reduction in amplitude, earlier acrophase, and an altered temporal relationship between central and lipid rhythms. Intrinsic circadian rhythm in the human plasma lipidome is preserved during healthy aging, but there is a significant advance in the phase and a reduction in the amplitude of circadian lipid profiles in older compared to younger adults.
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影响因子：
7.4
作者：
Bird, Susan S.;Marur, Vasant R.;Sniatynski, Matthew J.;Greenberg, Heather K.;Kristal, Bruce S.
通讯作者：
Kristal, Bruce S.
DOI：
10.1152/ajpregu.1997.273.5.r1764
发表时间：
1997-11-01
影响因子：
2.8
作者：
Cai, AH;Scarbrough, K;Wise, PM
通讯作者：
Wise, PM
影响因子：
7.4
作者：
Bird, Susan S.;Marur, Vasant R.;Kristal, Bruce S.
通讯作者：
Kristal, Bruce S.
影响因子：
5.6
作者：
Buysse, DJ;Monk, TH;Begley, A
通讯作者：
Begley, A
影响因子：
2.8
作者：
Carrier, J;Monk, TH;Kupfer, DJ
通讯作者：
Kupfer, DJ