Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment.
Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment.
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DOI：
10.1159/000150099
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发表时间：
2009
影响因子：
4.1
通讯作者：
Stier CT Jr
中科院分区：
文献类型：
--
作者：
Sabban EL;Schilt N;Serova LI;Masineni SN;Stier CT Jr
压力会引发关键的反应，包括血压和心率（HR）升高，以处理紧急情况并恢复体内平衡。然而，在压力停止后，这些影响的持续与许多与压力相关的疾病有关。在这里，我们研究了心血管和运动对单次和多次固定应激（IMO）反应的动力学和持久性，有或没有事先用促肾上腺皮质激素（ACTH）治疗。将无线电遥测探头植入雄性sd大鼠体内，持续监测平均动脉压（MAP）、HR和运动活动。大鼠每天（10 AM-noon）进行2小时的IMO应激，连续6天。第一次IMO引起的MAP（约30 mm Hg）和HR（约200 bpm）变化最大。每次IMO后，MAP和HR在剩余的光期升高，在随后的暗期，HR低于IMO前。我们进一步研究了ACTH升高到与IMO相似的水平是否会引起类似的效果，以及它是否会改变随后对IMO的反应。注射ACTH (13 IU/kg, sc)，触发MAP短暂升高，HR降低。每日注射ACTH 6次，恢复时间（8天）后，按上述方法固定大鼠。在IMO期间心血管反应相似，但ACTH预处理组在IMO停止后表现出差异。此外，IMO导致在黑暗（正常活动）阶段的运动活动大幅减少到与光明阶段相似的水平。在IMOs后，ACTH预处理组的运动活动恢复较慢。研究发现，在应激结束后，IMO触发的心血管和运动反应是明显的。此外，先前暴露于促肾上腺皮质激素会延迟应激停止后心血管和运动功能的恢复。
Stress triggers crucial responses, including elevated blood pressure and heart rate (HR), to handle the emergency and restore homeostasis. However, continuation of these effects following cessation of the stress is implicated with many stress related disorders. Here, we examine the kinetics and persistence of cardiovascular and locomotor responses to single and repeated immobilization stress (IMO), with and without prior treatment with adrenocorticotrophic hormone (ACTH). Radiotelemetry probes were implanted into male Sprague-Dawley rats to continually monitor mean arterial pressure (MAP), HR and locomotor activity. Rats were subjected to IMO stress for 2 hrs daily (10 AM-noon, 6 consecutive days). The first IMO induced the greatest change in MAP (about 30 mm Hg) and HR (about 200 bpm). Following each IMO, MAP and HR were elevated during the remaining light phase and in the subsequent dark phase, HR was lower than prior to IMO. We further examined whether elevation of ACTH to a level similar to IMO will elicit similar effects, and if it will alter subsequent responses to IMO. Injection of ACTH (13 IU/kg, sc), triggered short-lived rise in MAP, and decreased HR. After six daily injections of ACTH and recovery time (8 days), rats were immobilized as above. The cardiovascular responses were similar during the IMO, but the ACTH pretreated group displayed differences following cessation of the IMO. In addition, IMO led to a large reduction of locomotor activity during the dark (normally active) phase to levels similar to the light phase. Following the IMOs, locomotor activity recovered more slowly in ACTH pretreated group. The study revealed that IMO triggered cardiovascular and locomotor responses are evident after temination of the stress. In addition, prior exposure to ACTH delayed recovery in cardiovascular and locomotor functions following cessation of stress.
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影响因子：
3.3
作者：
Brown, S.;Chitravanshi, V. C.;Sapru, H. N.
通讯作者：
Sapru, H. N.
DOI：
10.1046/j.1440-1681.2001.03531.x
发表时间：
2001-10-01
影响因子：
2.9
作者：
Fraser, TB;Turner, SW;Whitworth, JA
通讯作者：
Whitworth, JA
影响因子：
--
作者：
GRUNFELD, JP
通讯作者：
GRUNFELD, JP
影响因子：
3.2
作者：
Masineni, SN;Chander, PN;Stier, CT
通讯作者：
Stier, CT
影响因子：
4.2
作者：
Kim, KS;Han, PL
通讯作者：
Han, PL