Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.
Loss of Calretinin in L5a impairs the formation of the barrel cortex leading to abnormal whisker-mediated behaviors.
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L5a 中钙视网膜蛋白的缺失会损害桶状皮层的形成，导致胡须介导的异常行为
DOI：
10.1186/s13041-021-00775-w
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发表时间：
2021-04-12
期刊：
影响因子：
3.6
通讯作者：
Zhao C
中科院分区：
文献类型：
--
作者：
Su M;Liu J;Yu B;Zhou K;Sun C;Yang M;Zhao C
啮齿动物的须桶皮层系统已成为研究感觉信息整合的理想模型。桶状皮层由桶状柱和隔状柱组成，它们分别接收来自颈神经和旁神经通路的信息输入。5a层涉及筒状电路和隔层电路，在信息集成中起关键作用。然而，5a层在桶状皮质发育中的作用尚不清楚。之前我们发现calretinin在5a层是动态表达的。在本研究中，我们对calretinin KO小鼠进行分析，发现calretinin消融后，5a层锥体神经元的树突复杂性和长度明显降低。5a层神经元的膜兴奋性和兴奋性突触传递增加。因此，桶的组织受到损害。第4层棘状星状细胞不能正常聚集，导致桶壁形成异常，桶/隔尺寸比明显减小。Calretinin KO小鼠在探索和须相关的触觉行为以及社会新奇偏好方面表现出缺陷。我们的研究扩展了我们对桶壁形成过程中5a层锥体神经元的认识，加深了对须-桶皮层系统发育的理解。
The rodent whisker-barrel cortex system has been established as an ideal model for studying sensory information integration. The barrel cortex consists of barrel and septa columns that receive information input from the lemniscal and paralemniscal pathways, respectively. Layer 5a is involved in both barrel and septa circuits and play a key role in information integration. However, the role of layer 5a in the development of the barrel cortex remains unclear. Previously, we found that calretinin is dynamically expressed in layer 5a. In this study, we analyzed calretinin KO mice and found that the dendritic complexity and length of layer 5a pyramidal neurons were significantly decreased after calretinin ablation. The membrane excitability and excitatory synaptic transmission of layer 5a neurons were increased. Consequently, the organization of the barrels was impaired. Moreover, layer 4 spiny stellate cells were not able to properly gather, leading to abnormal formation of barrel walls as the ratio of barrel/septum size obviously decreased. Calretinin KO mice exhibited deficits in exploratory and whisker-associated tactile behaviors as well as social novelty preference. Our study expands our knowledge of layer 5a pyramidal neurons in the formation of barrel walls and deepens the understanding of the development of the whisker-barrel cortex system.
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影响因子：
5.6
作者：
Fu JY;Yu XD;Zhu Y;Xie SZ;Tang MY;Yu B;Li XM
通讯作者：
Li XM
影响因子：
2.5
作者：
Hipp, J;Arabzadeh, E;König, P
通讯作者：
König, P
影响因子：
9.8
作者：
Bureau, Ingrid;von Saint Paul, Francisca;Svoboda, Karel
通讯作者：
Svoboda, Karel
影响因子：
3.4
作者：
Arakawa H;Akkentli F;Erzurumlu RS
通讯作者：
Erzurumlu RS
DOI：
10.1016/j.biocel.2009.05.007
发表时间：
2009-11-01
影响因子：
4
作者：
Camp, Aaron James;Wijesinghe, Rajiv
通讯作者：
Wijesinghe, Rajiv