A dual enhanced anti-bacterial strategy based on high chlorin e6-loaded polyethyleneimine functionalized graphene.
A dual enhanced anti-bacterial strategy based on high chlorin e6-loaded polyethyleneimine functionalized graphene.
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基于高二氯酸e6负载聚乙烯亚胺功能化石墨烯的双重增强抗菌策略
DOI：
10.1039/d0ra07976f
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发表时间：
2020-12-24
期刊：
影响因子：
3.9
通讯作者：
Liu K
中科院分区：
文献类型：
--
作者：
Wang J;Yang Y;Xu Y;Zhao L;Wang L;Yin Z;Li H;Tan H;Liu K
细菌感染一直是人类历史上的一个长期问题，如今由于抗生素的滥用而出现耐药性细菌，已成为严重威胁人类健康的问题。制备了高二氢卟酚e6（Ce 6）光敏剂负载的聚乙烯亚胺功能化石墨烯（PEI-G）纳米复合材料（PEI-G@ Ce 6）。Ce 6在PEI-G@ Ce 6上的负载量约为32.91wt%，高于其他纳米材料。制备的PEI-G@ Ce 6不仅提高了游离光敏剂Ce 6分子的光稳定性，而且保持了单线态氧的产生能力。基于PEI-G的物理抗菌作用和负载光敏剂Ce 6的光动力疗法（PDT）抗菌作用的双重增强，PEI-G@ Ce 6对金黄色葡萄球菌的抗菌效率增强。因此，本策略提供了一个有效的平台，以提高抗菌效率，更好地治疗伤口感染。
Bacterial infection has always been a long-term problem of human history and has nowadays became a severe threat to human health with the appearance of drug-resistant bacteria due to the abuse of antibiotics. In this study, a high chlorin e6 (Ce6) photosensitizer-loaded polyethyleneimine-functionalized graphene (PEI-G) nanocomposite (PEI-G@Ce6) was prepared. The loading capacity of Ce6 on PEI-G@Ce6 was approximately up to 32.91 wt%, which was higher than that of other nanomaterials. The as-prepared PEI-G@Ce6 not only improves the photostability of free photosensitizer Ce6 molecules but also maintains the ability of singlet oxygen generation. Based on the dual enhancement of the physical antibacterial effects of PEI-G and the photodynamic therapy (PDT) antibacterial effects of loaded photosensitizer Ce6, PEI-G@Ce6 exhibited enhanced antibacterial efficiency towards Staphylococcus aureus. Therefore, the present strategy provided an effective platform to improve antibacterial efficiency for the better treatment of wound infections.
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