The vitamin D pathway and mammographic breast density among postmenopausal women.
The vitamin D pathway and mammographic breast density among postmenopausal women.
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DOI：
10.1007/s10549-011-1726-5
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发表时间：
2012-01
影响因子：
3.8
通讯作者：
Skinner, Halcyon G.
中科院分区：
文献类型：
--
作者：
Sprague, Brian L.;Trentham-Dietz, Amy;Gangnon, Ronald E.;Buist, Diana S. M.;Burnside, Elizabeth S.;Bowles, Erin J. Aiello;Stanczyk, Frank Z.;Sisney, Gale S.;Skinner, Halcyon G.
实验室研究表明，维生素D具有许多化学预防特性，并且这些特性可能由维生素D途径中的其他分子介导或修饰，如甲状旁腺激素（PTH）或钙。然而，很少有流行病学数据探索维生素D对乳腺癌风险的影响，在这些其他分子的背景下。在威斯康星州乳腺密度研究中，我们检测了维生素D途径中的一组分子与乳腺摄影乳腺密度（乳腺癌风险的标志物）的关系。在威斯康星州的麦迪逊的乳房X线摄影诊所共招募了238名绝经后妇女（年龄55-70岁，无绝经后激素使用史）。受试者提供血液样本，分析25-羟基维生素D [25（OH）D]、PTH、胰岛素样生长因子1（IGF 1）、IGF结合蛋白3（IGFBP 3）、视黄醇和钙的水平。使用Cumulus软件测量乳腺密度百分比。在年龄校正分析中，25（OH）D与乳腺密度百分比呈正相关（P=0.05; 25（OH）D的第1和第4四分位数的平均密度百分比分别为11.3%和15.6%）。乳腺密度与PTH呈负相关（P=0.05; Q1 vs. Q4为16.0% vs. 11.4%），与IGF-1：IGFBP-3摩尔比呈正相关（P=0.02; Q1 vs. Q4为11.9% vs. 15.6%）。然而，在进一步校正体重指数（BMI; P>0.25）后，这些相关性均为零。在BMI和血清视黄醇、钙和雌二醇水平定义的亚组中，25（OH）D和乳腺密度之间的独立关系仍然为零。这些结果表明，在绝经后妇女中，维生素D途径的循环分子和乳房X线摄影乳腺密度之间没有强的独立关联。虽然维生素D仍然有可能影响乳腺癌风险，但我们的研究结果表明，这种影响将通过乳腺密度以外的途径介导。
Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. However, there is little epidemiologic data exploring the effects of vitamin D on breast cancer risk in the context of these other molecules. We examined a panel of molecules in the vitamin D pathway in relation to mammographic breast density, a marker of breast cancer risk, in the Wisconsin Breast Density Study. A total of 238 postmenopausal women (ages 55-70, with no history of postmenopausal hormone use) were enrolled from mammography clinics in Madison, Wisconsin. Subjects provided blood samples that were analyzed for levels of 25-hydroxy vitamin D [25(OH)D], PTH, insulin-like growth factor-1 (IGF1), IGF-binding protein 3 (IGFBP3), retinol, and calcium. Percent breast density was measured using Cumulus software. In age-adjusted analyses there was a positive association between 25(OH)D and percent breast density (P=0.05; mean percent density=11.3% vs. 15.6% for 1st vs. 4th quartile of 25(OH)D). Breast density was inversely associated with PTH (P=0.05; 16.0% vs. 11.4% for Q1 vs. Q4) and positively associated with the IGF-1:IGFBP-3 molar ratio (P=0.02; 11.9% vs. 15.6% for Q1 vs. Q4). However, these associations were all null after further adjustment for body mass index (BMI; P>0.25). The independent relation between 25(OH)D and breast density remained null among subgroups defined by BMI and serum levels of retinol, calcium, and estradiol. These results suggest no strong independent associations between the circulating molecules of the vitamin D pathway and mammographic breast density in postmenopausal women. While it remains possible that vitamin D could influence breast cancer risk, our results suggest that such an effect would be mediated through pathways other than breast density.
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