Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy.
Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy.
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DOI：
10.1016/j.ajog.2012.05.017
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发表时间：
2012-07
影响因子：
9.8
通讯作者：
Quesenberry, Charles P.
中科院分区：
文献类型：
--
作者：
Hedderson, Monique M.;Darbinian, Jeanne A.;Sridhar, Sneha B.;Quesenberry, Charles P.
关键词：
目的：检测孕前心脏代谢和炎症标志物与妊娠高血压疾病的风险。一项对3,380名妇女的回顾性队列研究，这些妇女在1984至1996年间参加了一次全面的多相健康体检(MHC)，并随后在北加州凯撒永久医院分娩。205名妇女被诊断为妊娠期高血压疾病。孕前超重/肥胖(体重指数≥25.0 kg/m2)、高血压前期和炎症(白细胞≥7.2103/µL)与妊娠高血压疾病独立相关[优势比(95%可信区间)分别为1.6(1.2~2.3)、2.1(1.5~2.8)和1.6(1.1~2.3)]。超重/肥胖和怀孕前有高血压前期的妇女患妊娠高血压疾病的风险比这两个危险因素水平正常的妇女高3.5倍。孕前心脏代谢和炎症危险因素分析可帮助临床医生识别高危妇女，以便及早干预或处理妊娠高血压疾病。
To examine prepregnancy cardiometabolic and inflammatory markers and subsequent risk of hypertensive disorders of pregnancy. A retrospective cohort study of 3,380 women who took part in a comprehensive multiphasic health checkup (MHC) exam between 1984 and 1996 and had a subsequent delivery in Kaiser Permanente Northern California. 205 women were diagnosed with a hypertensive disorder of pregnancy. Prepregnancy measurements of overweight/obesity (BMI ≥ 25.0 kg/m2), pre-hypertension and inflammation (leukocytes ≥ 7.2 103/µL) were independently associated with hypertensive disorder of pregnancy risk [odds ratios (95% confidence intervals): 1.6 (1.2–2.3), 2.1(1.5–2.8) and 1.6 (1.1–2.3), respectively]. Being overweight/obese and having pre-hypertension before pregnancy was associated with a 3.5-fold increased risk of hypertensive disorder of pregnancy compared with women with normal levels of both risk factors. Prepregnancy cardiometabolic and inflammation risk profile may help clinicians identify high risk women to target for early intervention or management of hypertensive disorder of pregnancy.
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