Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex.
Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex.
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人类运动皮层中记录的未分类尖峰和局部场电位的方向信息的可靠性
DOI：
10.1088/1741-2560/11/4/046007
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发表时间：
2014-08
影响因子：
4
通讯作者：
Hochberg LR
中科院分区：
文献类型：
--
作者：
Perge JA;Zhang S;Malik WQ;Homer ML;Cash S;Friehs G;Eskandar EN;Donoghue JP;Hochberg LR
目标。初级运动皮层记录的动作电位和局部场电位（LFPs）包含有关运动方向的信息。lfp被认为比动作电位对信号不稳定性具有更强的鲁棒性，这使得lfp与动作电位一起成为脑机接口应用的一个有前途的信号源。然而，相对较少的研究直接将lfp与动作电位在解码人类运动皮层运动方向方面的效用进行了比较。的方法。我们在两个人（T2和[S3]）执行运动想象任务时对运动皮层进行了皮质内多电极记录。然后，我们比较了LFPs的离线解码性能和从每个参与者一年期间记录的相同数据中提取的峰值。主要的结果。我们在多个LFP波段获得了运动方向和终点速度的离线预测精度，其中在最高（200-400 Hz） LFP频段表现最好，可能还包含低通滤波的动作电位。优选方向和定向调制指数的交叉频率相关性表明，动作电位放电速率（尖峰）与高频LFPs （70 ~ 400 Hz）之间的方向信息高度相似，在较低频段（0 ~ 7、10 ~ 40和50 ~ 65 Hz）之间的差异逐渐增大。峰值比任何单个LFP波段更准确地预测预期运动的方向，然而，所有LFP的综合解码在统计上与基于峰值的表现没有区别。随着尖峰信号质量（即信号幅度）和显著调制尖峰单元数量的减少，离线解码性能下降3.6[5.65]%/月（分别为T2和[S3]）。显著调制的LFP信号数量及其解码精度的下降也遵循类似的趋势（2.4[2.85]%/月，ANCOVA, p = 0.27[0.03]）。的意义。场电位提供了与未排序尖峰相当的离线解码性能。因此，lfp可以利用当前人类皮层内记录技术提供有用的外部设备控制。（临床试验注册号：NCT00912041）
Objective. Action potentials and local field potentials (LFPs) recorded in primary motor cortex contain information about the direction of movement. LFPs are assumed to be more robust to signal instabilities than action potentials, which makes LFPs, along with action potentials, a promising signal source for brain–computer interface applications. Still, relatively little research has directly compared the utility of LFPs to action potentials in decoding movement direction in human motor cortex. Approach. We conducted intracortical multi-electrode recordings in motor cortex of two persons (T2 and [S3]) as they performed a motor imagery task. We then compared the offline decoding performance of LFPs and spiking extracted from the same data recorded across a one-year period in each participant. Main results. We obtained offline prediction accuracy of movement direction and endpoint velocity in multiple LFP bands, with the best performance in the highest (200–400 Hz) LFP frequency band, presumably also containing low-pass filtered action potentials. Cross-frequency correlations of preferred directions and directional modulation index showed high similarity of directional information between action potential firing rates (spiking) and high frequency LFPs (70–400 Hz), and increasing disparity with lower frequency bands (0–7, 10–40 and 50–65 Hz). Spikes predicted the direction of intended movement more accurately than any individual LFP band, however combined decoding of all LFPs was statistically indistinguishable from spike-based performance. As the quality of spiking signals (i.e. signal amplitude) and the number of significantly modulated spiking units decreased, the offline decoding performance decreased 3.6[5.65]%/month (for T2 and [S3] respectively). The decrease in the number of significantly modulated LFP signals and their decoding accuracy followed a similar trend (2.4[2.85]%/month, ANCOVA, p = 0.27[0.03]). Significance. Field potentials provided comparable offline decoding performance to unsorted spikes. Thus, LFPs may provide useful external device control using current human intracortical recording technology. (Clinical trial registration number: NCT00912041.)
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
Shenoy KV
DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
2.5
作者：
Csicsvari, J;Henze, DA;Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
2.5
作者：
Ben-Shaul, Y;Stark, E;Abeles, M
通讯作者：
Abeles, M