Natural products in caries research: current (limited) knowledge, challenges and future perspective.
Natural products in caries research: current (limited) knowledge, challenges and future perspective.
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作者：
Jeon JG;Rosalen PL;Falsetta ML;Koo H
龋齿是世界范围内最普遍和最昂贵的口腔传染病。牢固附着在牙齿表面的有毒生物膜是与这种疾病相关的主要生物学因素。富含胞外多糖的生物膜基质的形成、环境的酸化和牙齿-生物膜界面处的持续低pH是调节龋齿发病机制的主要控制毒力因素。每一种都为预防提供了一个选择性的治疗目标。虽然氟化物以各种方式提供，仍然是预防龋齿的主要方法，但需要其他方法来提高其有效性。可用的抗牙斑方法是基于使用广谱杀微生物剂，例如氯己定。天然产物提供了丰富的结构多样的物质来源，具有广泛的生物活性，这可能是有用的替代或预防性防龋疗法的发展。然而，由于复杂的化学和分离程序，从天然产物中获得活性化合物是一种具有挑战性的方法。此外，大多数研究都集中在对葡聚糖合成以及细菌代谢和生长的一般抑制作用上，通常采用的方法没有解决疾病的病理生理学方面（例如生物膜中的细菌）和口腔中的暴露/滞留时间。因此，天然产品在龋齿预防中的真正价值和/或其确切的作用机制在很大程度上仍然未知。然而，已经鉴定出对致龋生物的毒性特性具有潜在活性的天然物质。本文综述了目前知识的差距，并提出了一个模型，用于调查使用天然产物的防龋化疗。
Dental caries is the most prevalent and costly oral infectious disease worldwide. Virulent biofilms firmly attached to tooth surfaces are prime biological factors associated with this disease. The formation of an exopolysaccharide-rich biofilm matrix, acidification of the milieu and persistent low pH at the tooth-biofilm interface are major controlling virulence factors that modulate dental caries pathogenesis. Each one offers a selective therapeutic target for prevention. Although fluoride, delivered in various modalities, remains the mainstay for the prevention of caries, additional approaches are required to enhance its effectiveness. Available antiplaque approaches are based on the use of broad-spectrum microbicidal agents, e.g. chlorhexidine. Natural products offer a rich source of structurally diverse substances with a wide range of biological activities, which could be useful for the development of alternative or adjunctive anticaries therapies. However, it is a challenging approach owing to complex chemistry and isolation procedures to derive active compounds from natural products. Furthermore, most of the studies have been focused on the general inhibitory effects on glucan synthesis as well as on bacterial metabolism and growth, often employing methods that do not address the pathophysiological aspects of the disease (e.g. bacteria in biofilms) and the length of exposure/retention in the mouth. Thus, the true value of natural products in caries prevention and/or their exact mechanisms of action remain largely unknown. Nevertheless, natural substances potentially active against virulent properties of cariogenic organisms have been identified. This review focuses on gaps in the current knowledge and presents a model for investigating the use of natural products in anticaries chemotherapy.
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影响因子：
2.8
作者：
Cross, Sarah E.;Kreth, Jens;Gimzewski, James K.
通讯作者：
Gimzewski, James K.
影响因子：
6.7
作者：
Darout, IA;Albandar, JM;Ali, RW
通讯作者：
Ali, RW
影响因子：
3.5
作者：
Castro, Myrella Lessio;do Nascimento, Andrea Mendes;Rosalen, Pedro L.
通讯作者：
Rosalen, Pedro L.
DOI：
10.1590/s0100-40422007000700003
发表时间：
2007-01-01
期刊：
Química Nova
影响因子：
--
作者：
Castro, Myrella Léssio;Cury, Jaime Aparecido;Koo, Hyun
通讯作者：
Koo, Hyun
影响因子：
7.6
作者：
BOWEN, WH;PEARSON, SK;YOUNG, DA
通讯作者：
YOUNG, DA