Gestational diabetes mellitus, maternal obesity, and adiposity in offspring.
Gestational diabetes mellitus, maternal obesity, and adiposity in offspring.
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DOI：
10.1016/j.jpeds.2013.11.063
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发表时间：
2014-04
影响因子：
5.1
通讯作者：
Xiang, Anny H.
中科院分区：
文献类型：
--
作者：
Page, Kathleen A.;Romero, Ana;Buchanan, Thomas A.;Xiang, Anny H.
目的：确定母亲妊娠期糖尿病（GDM）对墨西哥裔美国母子对后代肥胖的影响。这项研究包括62名墨西哥裔美国母亲和她们的后代。在指数妊娠期间记录母体GDM和正常血糖状态，并且母亲先前在年龄，BMI和胎次上匹配。当孩子的年龄在5岁到16岁之间时，对母子进行了研究。收集病史并测量人体测量值。主要结局指标为后代体重指数（BMI）、BMI z分数、BMI百分位数、臀围和腰围。与非GDM母亲的25个后代相比，GDM暴露的后代（n=37）具有更高的BMI（均p≤0.02）和更大的腰围和臀围（均p=0.002）。调整后代年龄、性别、Tanner阶段、出生体重、母乳喂养月数、母亲孕前BMI和妊娠体重增加后，GDM暴露组的差异减弱，但GDM暴露组的BMI z得分和BMI百分位数仍显著高于对照组（p<0.05）。在墨西哥裔美国儿童中，宫内暴露于GDM与更大的肥胖有关，这种关系不是由母亲肥胖介导的。与先前的报道相反，本研究仅包括墨西哥裔美国人，因此种族差异可能影响母亲GDM和母亲肥胖对后代肥胖的贡献。
To determine the effects of maternal gestational diabetes mellitus (GDM) on offspring adiposity in a well-characterized cohort of Mexican American mother-child pairs. This study included 62 Mexican American mothers and their index offspring. Maternal GDM and normal glucose status during index pregnancy were documented, and mothers were previously matched on age, BMI and parity. Mothers-child pairs were recruited when offspring were between the ages of 5 and 16 years. A medical history was collected and anthropometrics were measured. Main outcome measures were offspring body mass index (BMI), BMI z-scores, BMI percentiles and hip and waist circumferences. GDM exposed offspring (n=37) had greater measures of BMI (all p≤0.02) and greater waist and hip circumferences (both p=0.002) compared with 25 offspring of non-GDM mothers. Adjustment for offspring age, sex, Tanner Stage, birth weight, months of breastfeeding, maternal pre-pregnancy BMI and pregnancy weight gain attenuated the differences, but BMI z-score and BMI percentile remained significantly greater in the GDM exposed group (p<0.05). Intrauterine exposure to GDM is associated with greater adiposity in Mexican American children, and this relationship is not mediated by maternal obesity. In contrast to prior reports, this study included only Mexican Americans, thus ethnic variations may influence the contributions of maternal GDM and maternal obesity to offspring adiposity.
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影响因子：
4.9
作者：
Crume, T. L.;Ogden, L. G.;Mayer-Davis, E. J.;Hamman, R. F.;Norris, J. M.;Bischoff, K. J.;McDuffie, R.;Dabelea, D.
通讯作者：
Dabelea, D.
影响因子：
6.9
作者：
Bergman, Richard N.;Kim, Stella P.;Ader, Marilyn
通讯作者：
Ader, Marilyn
影响因子：
5.1
作者：
Crume, Tessa L.;Ogden, Lorraine;Dabelea, Dana
通讯作者：
Dabelea, Dana
影响因子：
7.7
作者：
Dabelea, D;Hanson, RL;Knowler, WC
通讯作者：
Knowler, WC
影响因子：
2.3
作者：
Baptiste-Roberts K;Nicholson WK;Wang NY;Brancati FL
通讯作者：
Brancati FL