The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: the EPOCH Study.
The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: the EPOCH Study.
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DOI：
10.1038/ijo.2011.254
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发表时间：
2012-04
影响因子：
4.9
通讯作者：
Dabelea, D.
中科院分区：
文献类型：
--
作者：
Crume, T. L.;Ogden, L. G.;Mayer-Davis, E. J.;Hamman, R. F.;Norris, J. M.;Bischoff, K. J.;McDuffie, R.;Dabelea, D.
关键词：
评价母乳喂养对参与EPOCH研究的糖尿病妊娠（ODP）后代和非糖尿病妊娠（ONDP）后代从出生到13岁的体重指数（BMI）生长轨迹的影响。有94名ODP和399名ONDP从出生到整个童年都有多项BMI测量。母乳月数的测量来自母亲的自我报告，将母乳喂养状态分类为充足（≥6个母乳月）或低（<6个母乳月）。构建混合线性效应模型，以评估母乳喂养对婴儿期（出生至27个月）和儿童期（27个月至13岁）BMI增长曲线的影响。与低母乳喂养的ODP相比，充分母乳喂养的ODP在儿童期的BMI增长轨迹较慢（p=0.047），特定时期的生长速度较慢，4至6岁（p=0.03）和6至9岁（p=0.01）之间存在显著差异。在ONDP中观察到类似的模式，婴儿期（p=0.03）和儿童期（p=0.0002）的平均BMI较低，儿童期生长轨迹较慢（p=0.0002）。与充分母乳喂养相关的ONDP中，特定时期的生长速度较慢，在12-26个月（p=0.02）、4-6岁（p=0.03）、6-9岁（p=0.0001）和9-13岁之间存在显着差异（p<.0001）。我们的研究提供了新的证据，表明母乳喂养与儿童BMI增长的长期影响有关，这种影响从婴儿期延伸到儿童早期和晚期。重要的是，这些影响也存在于高风险的后代中，在怀孕期间暴露于营养过剩。产后早期母乳喂养可能是降低儿童肥胖风险的关键机会。
To evaluate the influence of breastfeeding on the body mass index (BMI) growth trajectory from birth through 13 years of age among offspring of diabetic pregnancies (ODP) and offspring of non-diabetic pregnancies (ONDP) participating in the EPOCH study. There were 94 ODP and 399 ONDP who had multiple BMI measures obtained from birth throughout childhood. A measure of breast milk-months was derived from maternal self-report to categorize breastfeeding status as adequate (≥6 breast milk-months) or low (<6 breast milk-months). Mixed linear effects models were constructed to assess the impact of breastfeeding on the BMI growth curves during infancy (birth to 27 months) and childhood (27 months to 13 years). ODP who were adequately breastfed had a slower BMI growth trajectory during childhood (p=0.047) and slower period-specific growth velocity with significant differences between 4 to 6 years of age (p=0.03) and 6 to 9 years of age (p=0.01) compared to ODP with low breastfeeding. A similar pattern was seen in the ONDP, with adequate breastfeeding associated with lower average BMI in infancy (p=0.03) and childhood (p=0.0002) and a slower growth trajectory in childhood (p=0.0002). Slower period-specific growth velocity was seen among the ONDP associated with adequate breastfeeding with significant differences between 12–26 months (p=0.02), 4–6 years (p=0.03), 6–9 years (p=0.0001) and 9–13 years of age (p<.0001). Our study provides novel evidence that breastfeeding is associated with long-term effects on childhood BMI growth that extend beyond infancy into early and late childhood. Importantly, these effects are also present in the high-risk offspring, exposed to overnutrition during pregnancy. Breastfeeding in the early postnatal period may represent a critical opportunity to reduce the risk of childhood obesity.
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影响因子：
7.7
作者：
SILVERMAN, BL;RIZZO, T;METZGER, BE
通讯作者：
METZGER, BE
影响因子：
6.3
作者：
KARK, JD;TROYA, G;STEIN, Y
通讯作者：
STEIN, Y
影响因子：
5.1
作者：
Crume, Tessa L.;Ogden, Lorraine;Dabelea, Dana
通讯作者：
Dabelea, Dana
影响因子：
16.2
作者：
Rodekamp, E;Harder, T;Plagemann, A
通讯作者：
Plagemann, A
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB