Gestational diabetes and subsequent growth patterns of offspring: the National Collaborative Perinatal Project.
Gestational diabetes and subsequent growth patterns of offspring: the National Collaborative Perinatal Project.
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DOI：
10.1007/s10995-011-0756-2
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发表时间：
2012-01
影响因子：
2.3
通讯作者：
Brancati FL
中科院分区：
文献类型：
--
作者：
Baptiste-Roberts K;Nicholson WK;Wang NY;Brancati FL
我们的目的是检验这一假设，即宫内暴露于妊娠期糖尿病（GDM）预测儿童期生长，而不依赖于对婴儿出生体重的影响。我们对1959年至1965年期间参加全国围产期合作项目的28，358对母婴进行了前瞻性分析。这些后代被跟踪到7岁。484位母亲（1.7%）患有GDM。平均出生体重为3.2 kg（范围1.1-5.6 kg）。母亲的特征（年龄，教育，种族，家庭收入，孕前体重指数和怀孕体重增加）和儿童生长的措施（出生体重，体重在4岁和7岁）的GDM状态的差异显着（所有P < 0.05）。正如预期的那样，与非糖尿病母亲相比，GDM母亲生下的后代在出生时体重更高。患有GDM的母亲的后代在7岁时比未患有GDM的母亲的后代更大，如更大的体重、BMI和BMI z评分所示（均P < 0.05）。即使在调整婴儿出生体重后，7岁时的这些差异仍然存在。此外，在校正母亲BMI、妊娠体重增加、家庭收入、种族和出生体重后，患有GDM的母亲的后代在7岁时超重的几率比没有GDM的母亲的后代高61%[OR = 1.61（95%CI：1.07，1.28）]。我们的研究结果表明，母亲的GDM状态与子女的超重状态在儿童期。这种关系仅部分通过对出生体重的影响来介导。
Our objective was to test the hypothesis that intrauterine exposure to gestational diabetes [GDM] predicts childhood growth independent of the effect on infant birthweight. We conducted a prospective analysis of 28,358 mother-infant pairs who enrolled in the National Collaborative Perinatal Project between 1959 and 1965. The offspring were followed until age 7. Four hundred and eighty-four mothers (1.7%) had GDM. The mean birthweight was 3.2 kg (range 1.1–5.6 kg). Maternal characteristics (age, education, race, family income, pre-pregnancy body mass index and pregnancy weight gain) and measures of childhood growth (birthweight, weight at ages 4, and 7) differed significantly by GDM status (all P < 0.05). As expected, compared to their non-diabetic counterparts, mothers with GDM gave birth to offspring that had higher weights at birth. The offspring of mothers with GDM were larger at age 7 as indicated by greater weight, BMI and BMI z-score compared to the offspring of mothers without GDM at that age (all P < 0.05). These differences at age 7 persisted even after adjustment for infant birthweight. Furthermore, the offspring of mothers with GDM had a 61% higher odds of being overweight at age 7 compared to the offspring of mothers without GDM after adjustment for maternal BMI, pregnancy weight gain, family income, race and birthweight [OR = 1.61 (95%CI:1.07, 1.28)]. Our results indicate that maternal GDM status is associated with offspring overweight status during childhood. This relationship is only partially mediated by effects on birthweight.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
16.2
作者：
Gillman MW;Oakey H;Baghurst PA;Volkmer RE;Robinson JS;Crowther CA
通讯作者：
Crowther CA
影响因子：
5.2
作者：
Ravelli, ACJ;van der Meulen, JHP;Bleker, OP
通讯作者：
Bleker, OP
影响因子：
2.3
作者：
Huang, Jennifer S.;Lee, Tiffany A.;Lu, Michael C.
通讯作者：
Lu, Michael C.
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB