Longitudinal Assessment of Immune Responses to Repeated Annual Influenza Vaccination in a Human Cohort of Adults and Teenagers.
Longitudinal Assessment of Immune Responses to Repeated Annual Influenza Vaccination in a Human Cohort of Adults and Teenagers.
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成人和青少年人群对每年重复接种流感疫苗的免疫应答的纵向评估。
DOI：
10.3389/fimmu.2021.642791
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ross TM
中科院分区：
文献类型：
--
作者：
Sung MH;Shen Y;Handel A;Bahl J;Ross TM
背景：通过重复接种环境中疫苗引起的跨不同毒株的免疫反应来评估多组分疫苗的整体性能尚未得到充分研究，并且尚未对成人和青少年进行比较。方法：在佐治亚大学进行了一项人类队列研究，140 名受试者（86 名成人和 54 名青少年）在 2017/2018 和 2018/2019 流感季节重复接种疫苗。前瞻性收集宿主信息，并在每个季节接种疫苗前后采集血清样本。宿主因素与血凝抑制（HAI）综合评分重复测量之间的关联通过广义线性模型和广义估计方程进行评估。结果：整个样本（t = 4.26，df = 139，p < 0.001）和青少年组（t = 6.44，df = 53，p < 0.001）的平均 HAI 综合得分在第二季有所下降，而成年人的变化没有统计学意义（t = -1.14，df = 85，p = 0.26）。当通过先前的疫苗接种进行分层时，在成人中观察到了两个方向变化的混合模式。此外，回归分析表明，年龄和BMI对总体人群（β = 0.005；95% CI，0.0008-0.01）和成人（β = 0.005；95% CI，0.0005-0.01）的HAI综合评分存在交互作用。结论：我们的研究发现，当成人和青少年连续几年重复接种疫苗时，疫苗会引发不同的免疫反应。在总体人群和成年人中发现了年龄和 BMI 对 HAI 综合评分的交互影响。
Background: The overall performance of a multiple component vaccine assessed by the vaccine-elicited immune responses across various strains in a repeated vaccination setting has not been well-studied, and the comparison between adults and teenagers is yet to be made. Methods: A human cohort study was conducted at the University of Georgia, with 140 subjects (86 adults and 54 teenagers) repeatedly vaccinated in the 2017/2018 and 2018/2019 influenza seasons. Host information was prospectively collected, and serum samples were collected before and after vaccination in each season. The association between host factors and repeated measures of hemagglutination inhibition (HAI) composite scores was assessed by generalized linear models with generalized estimating equations. Results: The mean HAI composite scores for the entire sample (t = 4.26, df = 139, p < 0.001) and the teenager group (t = 6.44, df = 53, p < 0.001) declined in the second season, while the changes in the adults were not statistically significant (t = −1.14, df = 85, p = 0.26). A mixture pattern of changes in both directions was observed in the adults when stratified by prior vaccination. In addition, the regression analysis suggested an interactive effect of age and BMI on the HAI composite scores in the overall population (beta = 0.005; 95% CI, 0.0008–0.01) and the adults (beta = 0.005; 95% CI, 0.0005–0.01). Conclusions: Our study found distinct vaccine-elicited immune responses between adults and teenagers when both were repeatedly vaccinated in consecutive years. An interactive effect of age and BMI on the HAI composite scores were identified in the overall population and the adults.
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影响因子：
6.9
作者：
Paich, Heather A.;Sheridan, Patricia A.;Handy, Jean;Karlsson, Erik A.;Schultz-Cherry, Stacey;Hudgens, Michael G.;Noah, Terry L.;Weir, Samuel S.;Beck, Melinda A.
通讯作者：
Beck, Melinda A.
影响因子：
8
作者：
Abreu, Rodrigo B.;Kirchenbaum, Greg A.;Ross, Ted M.
通讯作者：
Ross, Ted M.
影响因子：
5.5
作者：
Thompson, Mark G.;Naleway, Allison;Gaglani, Manjusha
通讯作者：
Gaglani, Manjusha
影响因子：
3.7
作者：
Nuñez IA;Carlock MA;Allen JD;Owino SO;Moehling KK;Nowalk P;Susick M;Diagle K;Sweeney K;Mundle S;Vogel TU;Delagrave S;Ramgopal M;Zimmerman RK;Kleanthous H;Ross TM
通讯作者：
Ross TM
DOI：
10.1073/pnas.96.24.14001
发表时间：
1999-11-23
影响因子：
11.1
作者：
Smith, DJ;Forrest, S;Perelson, AS
通讯作者：
Perelson, AS