Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains.
Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains.
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DOI：
10.1371/journal.pone.0185666
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ross TM
中科院分区：
文献类型：
--
作者：
Nuñez IA;Carlock MA;Allen JD;Owino SO;Moehling KK;Nowalk P;Susick M;Diagle K;Sweeney K;Mundle S;Vogel TU;Delagrave S;Ramgopal M;Zimmerman RK;Kleanthous H;Ross TM
大多数人对流感病毒已有免疫力。在这项研究中，志愿者（18-85岁）在2013年至2016年的连续四个流感季节接种了分离灭活Fluzone™流感疫苗。由于疫苗株的变化，评估了重复接种对抗体广度和持久性的影响。在接种疫苗后（第21天），抗血凝素（HA）结合抗体和血凝素抑制（HAI）活性在所有年龄组中均增加。然而，年轻受试者对疫苗株保持血清保护滴度，这导致老年人血清转换率更高，因为老年受试者的HAI滴度在下一个季节之前更有可能下降。从20世纪80年代中期至今，年轻受试者对历史和当代H1和H3疫苗株具有显著的HAI活性。相比之下，老年受试者在所有年份对H1菌株都有HAI活性，但在1918-1950年期间更可能对老年菌株有HAI活性。与2000年代中期至今识别H3N2流感病毒的年轻受试者相比，他们对H3病毒的HAI谱也更有限。然后根据受试者是否从接种前的血清阴性或血清阳性状态转化为疫苗接种者进行分类。无论年龄大小，免疫召回或对抗原性相关菌株的“反向增强”与血清转化为疫苗菌株有关。总体而言，年轻人和老年人在接种流感疫苗后都有能力产生广泛的免疫反应。本报告描述了不同年龄组的印迹暴露是如何不同的，如何影响抗体对过去血凝素抗原变异的交叉反应性，以及如何塑造当前分裂灭活流感疫苗引起的免疫反应。了解目前的流感疫苗如何受到不同年龄人群已有免疫的影响，对于设计下一代“通用”或广泛保护性流感疫苗至关重要。
Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18–85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The impact of repeated vaccination on breadth and durability of antibodies was assessed as a result of vaccine strain changes. Total IgG anti-hemagglutinin (HA) binding antibodies and hemagglutination-inhibition (HAI) activity increased in all age groups against both influenza A HA components in the vaccine post-vaccination (day 21). However, younger subjects maintained seroprotective titers to the vaccine strains, which resulted in higher seroconversion rates in the elderly, since the HAI titers in elderly subjects were more likely to decline prior to the next season. Young subjects had significant HAI activity against historical, as well as contemporary H1 and H3 vaccine strains from the mid-1980s to present. In contrast, elderly subjects had HAI activity to H1 strains from all years, but were more likely to have HAI activity to older strains from 1918-1950s. They also had a more restricted HAI profile against H3 viruses compared to young subjects recognizing H3N2 influenza viruses from the mid-2000s to present. Vaccine recipients were then categorized by whether subjects seroconverted from a seronegative or seropositive pre-vaccination state. Regardless of age, immunological recall or ‘back-boosting’ to antigenically related strains were associated with seroconversion to the vaccine strain. Overall, both younger and older people have the ability to mount a breadth of immune responses following influenza vaccination. This report describes how imprinting exposure differs across age groups, influences antibody cross-reactivity to past hemagglutinin antigenic variants, and shapes immune responses elicited by current split inactivated influenza vaccines. Understanding how current influenza vaccines are influenced by pre-existing immunity in people of different ages is critical for designing the next-generation of ‘universal’ or broadly-protective influenza vaccines.
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DOI：
10.1084/jem.20130323
发表时间：
2013-11-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Deenick EK;Avery DT;Chan A;Berglund LJ;Ives ML;Moens L;Stoddard JL;Bustamante J;Boisson-Dupuis S;Tsumura M;Kobayashi M;Arkwright PD;Averbuch D;Engelhard D;Roesler J;Peake J;Wong M;Adelstein S;Choo S;Smart JM;French MA;Fulcher DA;Cook MC;Picard C;Durandy A;Klein C;Holland SM;Uzel G;Casanova JL;Ma CS;Tangye SG
通讯作者：
Tangye SG
DOI：
10.15585/mmwr.mm6606a3
发表时间：
2017-02-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Flannery B;Chung JR;Thaker SN;Monto AS;Martin ET;Belongia EA;McLean HQ;Gaglani M;Murthy K;Zimmerman RK;Nowalk MP;Jackson ML;Jackson LA;Foust A;Sessions W;Berman L;Spencer S;Fry AM
通讯作者：
Fry AM
影响因子：
4.6
作者：
Lefebvre JS;Masters AR;Hopkins JW;Haynes L
通讯作者：
Haynes L
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM
影响因子：
4.4
作者：
Frasca, Daniela;Diaz, Alain;Blomberg, Bonnie B.
通讯作者：
Blomberg, Bonnie B.