An Open-Label Pilot Study of Metformin as a Concomitant Therapy on Patients with Prostate Cancer Undergoing Androgen Deprivation Treatment
An Open-Label Pilot Study of Metformin as a Concomitant Therapy on Patients with Prostate Cancer Undergoing Androgen Deprivation Treatment
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二甲双胍联合治疗接受雄激素剥夺治疗的前列腺癌患者的开放标签试点研究
DOI：
10.1159/000448691
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Zhu W;Xu H;Ma J;Guo J;Xue W;Gu B;Sheng L;Yao X;Sun F;Gong J;Qiu W;Ding Q;Jiang H
目的：本研究旨在评估二甲双胍对接受雄激素剥夺治疗（ADT）的中国男性胰岛素、C肽和体重的影响。研究方法：2013年3月至2014年6月期间，从上海7家医院招募了62例因接受ADT治疗而新诊断的前列腺癌（PCa）患者。患者随机分别接受ADT（n = 31）和ADT +二甲双胍（n = 31）治疗6个月。分别于治疗开始和结束时测定空腹和餐后血清胰岛素、C肽、血糖、前列腺特异性抗原、体重指数（BMI）和腰围（WC）。结果：两组的基线特征相似。对照基线水平，ADT组的空腹血糖水平（p = 0.01）和WC水平（p = 0.04）显著高于ADT +二甲双胍组。胰岛素、C肽和BMI水平无显著差异。结论：美托洛尔可能是接受雄激素剥夺治疗的PCa患者的有效伴随治疗。
Purpose: The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). Methods: Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai. Patients were randomized to respectively receive ADT (n = 31) and ADT + metformin (n = 31) for 6 months. Fasting and postprandial serum levels of insulin and C-peptide, blood glucose, prostate specific antigen, body mass index (BMI) and waist circumference (WC) were measured at the beginning and end of 6-month treatment. Results: Baseline characteristics were comparable between the 2 groups. Controlling for baseline levels, the ADT group had significantly higher levels of fasting glucose (p = 0.01) and higher WC (p = 0.04) than the ADT + metformin group. The levels of insulin, C-peptide and BMI did not differ significantly. Conclusions: Metformin may be potentially efficient as a concomitant therapy on patients with PCa undergoing androgen deprivation treatment.
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影响因子：
1
作者：
R. Barbieri;A. Gargiulo
通讯作者：
R. Barbieri;A. Gargiulo
影响因子：
10.3
作者：
Hsing, AW;Chua, S;Stanczyk, FZ
通讯作者：
Stanczyk, FZ
影响因子：
2.8
作者：
Cox, Michael E.;Gleave, Martin E.;Pollak, Michael
通讯作者：
Pollak, Michael
影响因子：
2.3
作者：
Wright, Jonathan L.;Stanford, Janet L.
通讯作者：
Stanford, Janet L.
影响因子：
158.5
作者：
STUMVOLL, M;NURJHAN, N;GERICH, JE
通讯作者：
GERICH, JE