Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high-resolution MRI at 4 Tesla: preliminary results.
Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high-resolution MRI at 4 Tesla: preliminary results.
复制标题
颞叶癫痫中的子场萎缩模式，有或没有中性硬化症，可通过4特斯拉的高分辨率MRI检测到：初步结果。
DOI：
10.1111/j.1528-1167.2009.02010.x
复制
发表时间：
2009-06
期刊：
影响因子：
5.6
通讯作者：
Weiner MW
中科院分区：
文献类型：
--
作者：
Mueller SG;Laxer KD;Barakos J;Cheong I;Garcia P;Weiner MW
在4特斯拉下的高分辨率磁共振成像(MRI)描绘了在1.5特斯拉下看不到的海马体内部结构的细节，因此允许在体内分割不同的海马子区域。这项研究的目的是测试是否可以在伴内侧颞叶硬化(TLE-MTS)和不伴海马硬化(TLE-NO)的颞叶癫痫(TLE)中检测到不同的亚场萎缩模式。34例对照组(15例TLE-MTS和18例TLE-NO)获得高分辨率T2加权海马区图像。内嗅皮层(ERC)、下丘脑(SUB)、CA1、CA2和CA3，以及齿状回(CA3和DG)的体积采用手动分割方案确定。TLE-MTS同侧CA1、CA2、CA3、DG及海马区总体积明显小于对照组或TLE-NO。平均同侧CA1和CA3&DGz评分显著低于同侧CA2、ERC和SUB Z评分。TLE-NO在IPSI或对侧的不同亚区或海马区z分数之间均无显著差异。使用z-Score≤−2.0判定严重的体积丢失，发现TLE-MTS的萎缩模式如下：CA1萎缩，CA3和DG萎缩，CA1和CA3和DG萎缩，以及整个海马区萎缩。三种TLE-NO均有明显的亚场萎缩：对侧亚萎缩，双侧CA3和DG萎缩，同侧ERC和亚萎缩。在4特斯拉高分辨率MRI上使用手动分割方案，我们发现了TLE-MTS中描述的同侧CA1和CA3和DG的特征性萎缩。尽管海马区总体积正常，但仍有17%的TLE-NO有亚场萎缩。这些发现表明，与标准的海马体积测量相比，高分辨率MRI和子场体积测量提供了更好的信息。
High-resolution magnetic resonance imaging (MRI) at 4 Tesla depicts details of the internal structure of the hippocampus not visible at 1.5 Tesla, and so allows for in vivo parcellation of different hippocampal subfields. The aim of this study was to test if distinct subfield atrophy patterns can be detected in temporal lobe epilepsy (TLE) with mesial temporal sclerosis (TLE-MTS) and without (TLE-no) hippocampal sclerosis. High-resolution T2-weighted hippocampal images were acquired in 34 controls: 15 TLE-MTS and 18 TLE-no. Entorhinal cortex (ERC), subiculum (SUB), CA1, CA2, and CA3, and dentate (CA3&DG) volumes were determined using a manual parcellation scheme. TLE-MTS had significantly smaller ipsilateral CA1, CA2, CA3&DG, and total hippocampal volume than controls or TLE-no. Mean ipsilateral CA1 and CA3&DG z-scores were significantly lower than ipsilateral CA2, ERC, and SUB z-scores. There were no significant differences between the various subfield or hippocampal z-scores on either the ipsi- or the contralateral side in TLE-no. Using a z-score ≤ −2.0 to identify severe volume loss, the following atrophy patterns were found in TLE-MTS: CA1 atrophy, CA3&DG atrophy, CA1 and CA3& DG atrophy, and global hippocampal atrophy. Significant subfield atrophy was found in three TLE-no: contralateral SUB atrophy, bilateral CA3&DG atrophy, and ipsilateral ERC and SUB atrophy. Using a manual parcellation scheme on 4 Tesla high-resolution MRI, we found the characteristic ipsilateral CA1 and CA3&DG atrophy described in TLE-MTS. Seventeen percent of the TLE-no had subfield atrophy despite normal total hippocampal volume. These findings indicate that high-resolution MRI and subfield volumetry provide superior information compared to standard hippocampal volumetry.
登录
查看更多内容
影响因子：
9.9
作者：
Lin, JJ;Salamon, N;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1016/s0896-6974(05)80120-3
发表时间：
1992-01-01
期刊：
JOURNAL OF EPILEPSY
影响因子：
--
作者：
WYLER, AR;DOHAN, FC;BERRY, AD
通讯作者：
BERRY, AD
影响因子：
5.7
作者：
Mueller, S. G.;Schuff, N.;Weiner, M. W.
通讯作者：
Weiner, M. W.
影响因子：
2.6
作者：
De Vita, E;Thomas, DL;Ordidge, RJ
通讯作者：
Ordidge, RJ
影响因子：
9.9
作者：
JACKSON, GD;KUZNIECKY, RI;CASCINO, GD
通讯作者：
CASCINO, GD