Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
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DOI：
10.3349/ymj.2007.48.2.233
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发表时间：
2007-04-30
影响因子：
2.4
通讯作者：
Park KK
中科院分区：
文献类型：
--
作者：
Cha IH;Park JY;Chung WY;Choi MA;Kim HJ;Park KK
口腔癌是世界上第五大常见癌症，占所有癌症死亡的6.5%。由于口腔癌的主要危险因素之一是烟草使用，我们假设编码烟草致癌物代谢酶的多态性基因可能在口腔癌易感性中发挥作用。为探讨韩国人群中CYP 1A 1和GSTM 1基因多态性与口腔鳞状细胞癌（OSCC）风险之间的关系，在72例经组织学证实的原发性OSCC患者和221例健康对照者中检测了CYP 1A 1 Msp 1和GSTM 1无效多态性的患病率。在CYP 1A 1（m2/m2）纯合子基因型（OR = 3.8，95%CI = 1.9-7.7）的受试者中观察到口腔癌的风险显著增加，但在GSTM 1缺失基因型（OR = 0.7，95%CI = 0.4-1.3）的受试者中未观察到口腔癌风险显著增加。无论有无吸烟史，纯合子CYP 1A 1（m2/m2）基因型受试者的口腔癌风险均显著增加（吸烟者; OR = 4.4; 95% CI = 1.2-16.3;非吸烟者OR = 4.9; 95% CI=1.9-12.5）。使用潜在的最具保护性的基因型GSTM 1（+）/CYP 1A 1 [（m1/m1）+（m1/m2）]作为参照组，在GSTM 1（+）/CYP 1A 1（m2/m2）受试者中观察到口腔癌风险增加（OR = 2.0，95% CI = 0.8-5.2）和GSTM 1（-）/CYP 1A 1（m2/m2）（OR=4.9，95% CI = 1.5-15.5）基因型（p < 0.009，（χ2趋势检验）。我们的研究结果表明，具有CYP 1A 1（m2/m2）和GSTM 1（-）基因型的个体对OSCC高度易感，并且CYP 1A 1（m2/m2）基因型与韩国人OSCC风险增加密切相关。
Oral cancer is the fifth most common form of cancer in the world and comprises 6.5% of all cancer deaths. Since one of the major risk factors for oral cancer is tobacco use, we hypothesized that polymorphic genes coding for tobacco carcinogen-metabolizing enzymes may play a role in oral cancer susceptibility. To investigate the association between polymorphisms of the CYP1A1 and GSTM1 genes and risks for oral squamous cell carcinoma (OSCC) in the Korean population, the prevalence of the CYP1A1 Mspl and GSTM1 null polymorphisms were examined in 72 patients with histologically confirmed primary OSCC, as well as in 221 healthy control subjects. A significant risk increase for oral cancer was observed among subjects with the homozygous CYP1A1 (m2/m2) genotype (OR = 3.8, 95% CI = 1.9-7.7), but not the GSTM1 null genotype (OR = 0.7, 95% CI = 0.4-1.3). Risk for oral cancer was significantly increased in subjects with the homozygous CYP1A1 (m2/m2) genotype, regardless of smoking history (smokers; OR = 4.4; 95% CI = 1.2-16.3; non-smokers OR = 4.9; 95% CI=1.9-12.5). Using the potentially most protective genotype GSTM1 (+)/CYP1A1 [(m1/m1)+(m1/m2)] as the reference group, an increased risk for oral cancer was observed among subjects with the GSTM1 (+)/ CYP1A1 (m2/m2) (OR = 2.0, 95% CI = 0.8-5.2), and GSTM1 (-)/ CYP1A1 (m2/m2) (OR=4.9, 95% CI = 1.5-15.5) genotypes (p < 0.009, (χ2 trend test). Our results suggest that individuals with a genotype of CYP1A1 (m2/m2) and GSTM1 (-) are highly susceptible for OSCC and that the CYP1A1 (m2/m2) genotype is closely associated with increased risk of OSCC in Koreans.
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影响因子：
3.5
作者：
KAWAJIRI, K;NAKACHI, K;WATANABE, J
通讯作者：
WATANABE, J
影响因子：
4.8
作者：
Drummond, SN;De Marco, L;Gomez, RS
通讯作者：
Gomez, RS
DOI：
10.1016/0027-5107(91)90022-g
发表时间：
1991-04-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
NEBERT, DW
通讯作者：
NEBERT, DW
DOI：
10.1093/jnci/85.14.1159
发表时间：
1993-07-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BELL, DA;TAYLOR, JA;LUCIER, GW
通讯作者：
LUCIER, GW
影响因子：
4.7
作者：
Buch, SC;Notani, PN;Bhisey, RA
通讯作者：
Bhisey, RA