Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia.
Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia.
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DOI：
10.1001/archgenpsychiatry.2011.2084
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发表时间：
2012-09
影响因子：
--
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Gogtay, Nitin;Hua, Xue;Stidd, Reva;Boyle, Christina P.;Lee, Suh;Weisinger, Brian;Chavez, Alex;Giedd, Jay N.;Clasen, Liv;Toga, Arthur W.;Rapoport, Judith L.;Thompson, Paul M.
儿童期精神分裂症（COS）患者的非精神病性兄弟姐妹在早期与其先证者共享皮质灰质异常这些在兄弟姐妹18岁时正常化，这表明精神分裂症的灰质异常可能是一种年龄特异性的内表型。COS患者还表现出明显的白质（WM）生长缺陷，这在非精神病性兄弟姐妹中尚未发现。研究非精神病性COS患者兄弟姐妹WM生长差异。纵向（5年）解剖磁共振成像研究使用一种新的基于张量的形态分析来绘制WM生长。马里兰州贝塞斯达国立卫生研究院临床中心。49例COS患者健康兄弟姐妹（平均[SD]年龄16.1[5.3]岁，男性19例，女性30例）和57例健康对照（年龄16.9[5.3]岁，男性29例，女性28例）。磁共振成像。白质增长率。我们比较了3个年龄段的WM增长率。在最年轻的年龄组（7至<14岁）中，我们发现生长速度有显著差异，COS患者的兄弟姐妹在大脑顶叶的WM生长速度比年龄匹配的健康对照组慢（错误发现率，q = 0.05；双侧顶叶WM的临界P = 0.001； post - hoc分析仅在左侧发现生长速度差异，临界P = 0.004）。在老年人群中没有发现生长速率的差异。在三维地图中，兄弟姐妹的生长速度甚至在晚年似乎超过了健康个体，至少在大脑的局部，但这种影响在多次比较校正后无法存活。在首次对COS患者的非精神病性兄弟姐妹进行的纵向研究中，兄弟姐妹表现出早期WM生长缺陷，并随着年龄的增长而正常化。正如之前关于灰质的报道，WM的增长也可能是一种年龄特异性的内表型，随着年龄的增长呈现代偿性正常化。
Nonpsychotic siblings of patients with childhood-onset schizophrenia (COS) share cortical gray matter abnormalities with their probands at an early age; these normalize by the time the siblings are aged 18 years, suggesting that the gray matter abnormalities in schizophrenia could be an age-specific endophenotype. Patients with COS also show significant white matter (WM) growth deficits, which have not yet been explored in nonpsychotic siblings. To study WM growth differences in non-psychotic siblings of patients with COS. Longitudinal (5-year) anatomic magnetic resonance imaging study mapping WM growth using a novel tensor-based morphometry analysis. National Institutes of Health Clinical Center, Bethesda, Maryland. Forty-nine healthy siblings of patients with COS (mean [SD] age, 16.1[5.3] years; 19 male, 30 female) and 57 healthy persons serving as controls (age, 16.9[5.3] years; 29 male, 28 female). Magnetic resonance imaging. White matter growth rates. We compared the WM growth rates in 3 age ranges. In the youngest age group (7 to <14 years), we found a significant difference in growth rates, with siblings of patients with COS showing slower WM growth rates in the parietal lobes of the brain than age-matched healthy controls (false discovery rate, q = 0.05; critical P = .001 in the bilateral parietal WM; a post hoc analysis identified growth rate differences only on the left side, critical P =.004). A growth rate difference was not detectable at older ages. In 3-dimensional maps, growth rates in the siblings even appeared to surpass those of healthy individuals at later ages, at least locally in the brain, but this effect did not survive a multiple comparisons correction. In this first longitudinal study of nonpsychotic siblings of patients with COS, the siblings showed early WM growth deficits, which normalized with age. As reported before for gray matter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with age.
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影响因子：
10.6
作者：
Bartzokis, G;Nuechterlein, KH;Mintz, J
通讯作者：
Mintz, J
影响因子：
6.6
作者：
Boos, Heleen B. M.;Cahn, Wiepke;Kahn, Rene S.
通讯作者：
Kahn, Rene S.
影响因子：
3.7
作者：
Dinov, Ivo;Lozev, Kamen;Toga, Arthur
通讯作者：
Toga, Arthur
影响因子：
--
作者：
Gogtay, Nitin;Greenstein, Deanna;Rapoport, Judith
通讯作者：
Rapoport, Judith
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y