A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats.
A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats.
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DOI：
10.1186/s12951-021-00822-7
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发表时间：
2021-03-22
影响因子：
10.2
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Chen X;Zhang Y;Zhang H;Zhang L;Liu L;Cao Y;Ran H;Tian J
缺血性心脏病（IHD）是世界范围内发病率和死亡率的主要原因，并造成严重的经济负担。因此，在心肌缺血早期进行及时准确的诊断和监测是至关重要的。目前，纳米颗粒（NPs）因其无创、高安全性和实时动态成像的优点，为心脏病的诊断提供了有价值的信息，已成为多模态成像的有前途的工具。在这项研究中，我们制备了一种靶向纳米探针（称为IMTP-Fe3O4-PFH NPs），具有增强超声（US）、光声（PA）和磁共振（MR）性能，用于大鼠模型缺血心肌的直接和无创视觉成像。成功设计的纳米探针具有纳米尺寸、良好的稳定性、声液滴蒸发相变（ADV）和良好的安全性等优异性能。对缺氧损伤细胞和模型大鼠心脏具有明显的靶向作用。NPs经模型大鼠尾静脉注射后，体内成像结果显示US/PA/MR信号明显增强，表明纳米探针鉴别缺血心肌的可行性显著。IMTP-Fe3O4-PFH NPs可能是一个很有前途的纳米平台，用于缺血心肌的早期检测和靶向治疗。在线版本包含补充材料，可在10.1186/s12951-021-00822-7获得。
Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the early stage of myocardial ischemia. Currently, nanoparticles (NPs) have emerged as promising tools for multimodal imaging, because of their advantages of non-invasion, high-safety, and real-time dynamic imaging, providing valuable information for the diagnosis of heart diseases. In this study, we prepared a targeted nanoprobe (termed IMTP-Fe3O4-PFH NPs) with enhanced ultrasound (US), photoacoustic (PA), and magnetic resonance (MR) performance for direct and non-invasive visual imaging of ischemic myocardium in a rat model. This successfully designed nanoprobe had excellent properties such as nanoscale size, good stability, phase transformation by acoustic droplet vaporization (ADV), and favorable safety profile. Besides, it realized obvious targeting performance toward hypoxia-injured cells as well as model rat hearts. After injection of NPs through the tail vein of model rats, in vivo imaging results showed a significantly enhanced US/PA/MR signal, well indicating the remarkable feasibility of nanoprobe to distinguish the ischemic myocardium. IMTP-Fe3O4-PFH NPs may be a promising nanoplatform for early detection of ischemic myocardium and targeted treatment under visualization for the future. The online version contains supplementary material available at 10.1186/s12951-021-00822-7.
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影响因子：
18.3
作者：
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影响因子：
12.4
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
9.7
作者：
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通讯作者：
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