Vector biology meets disease control: using basic research to fight vector-borne diseases.
Vector biology meets disease control: using basic research to fight vector-borne diseases.
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DOI：
10.1038/s41564-018-0214-7
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发表时间：
2019-01
影响因子：
28.3
通讯作者：
Catteruccia F
中科院分区：
文献类型：
--
作者：
Shaw WR;Catteruccia F
由昆虫传播的人类病原体是一个全球性问题，特别是由蚊子传播的病原体；例如，由按蚊传播的疟疾寄生虫，以及由伊蚊携带的登革热、寨卡和基孔肯雅热等病毒。在过去15年中，通过使用以杀虫剂为基础的方法控制蚊媒，疟疾的流行率大幅下降，病毒暴发得到控制。然而，疾病控制现在受到昆虫种群中令人震惊的抗药性的威胁，这促使需要开发新一代特定战略，以减少媒介媒介的传播。在这里，我们回顾了昆虫生物学和昆虫-病原体相互作用方面知识的增加如何刺激了媒介控制的新概念和新工具。我们专注于干扰病原体在其载体内的发展或直接影响昆虫生存的策略，包括加强载体介导的免疫控制，操纵昆虫微生物组，或使用强大的新遗传工具，如CRISPR-CAS系统来编辑载体基因组。最后，我们对执行障碍以及未来几年必须填补的知识空白提出了看法，以便安全地实现这些新战略的潜力，消除媒介传播疾病的祸害。
Human pathogens that are transmitted by insects are a global problem, particularly those vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species, and viruses such as dengue, Zika and chikungunya that are carried by Aedes mosquitoes. Over the past 15 years, the prevalence of malaria has been substantially reduced and virus outbreaks have been contained by controlling mosquito vectors using insecticide-based approaches. However, disease control is now threat-ened by alarming rates of insecticide resistance in insect populations, prompting the need to develop a new generation of specific strategies that can reduce vector-mediated transmission. Here, we review how increased knowledge in insect biology and insect–pathogen interactions is stimulating new concepts and tools for vector control. We focus on strategies that either interfere with the development of pathogens within their vectors or directly impact insect survival, including enhancement of vector-mediated immune control, manipulation of the insect microbiome, or use of powerful new genetic tools such as CRISPR– Cas systems to edit vector genomes. Finally, we offer a perspective on the implementation hurdles as well as the knowledge gaps that must be filled in the coming years to safely realize the potential of these novel strategies to eliminate the scourge of vector-borne disease.
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影响因子：
3.7
作者：
Apte-Deshpande A;Paingankar M;Gokhale MD;Deobagkar DN
通讯作者：
Deobagkar DN
影响因子：
4.6
作者：
Bando, Hironori;Okado, Kiyoshi;Guelbeogo, Wamdaogo M.;Badolo, Athanase;Aonuma, Hiroka;Nelson, Bryce;Fukumoto, Shinya;Xuan, Xuenan;Sagnon, N'Fale;Kanuka, Hirotaka
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Kanuka, Hirotaka
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3.8
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通讯作者：
Scott TW
影响因子：
3.8
作者：
Antonova, Yevgeniya;Alvarez, Kanwal S.;Kim, Yu Jung;Kokoza, Vladimir;Raikhel, Alexander S.
通讯作者：
Raikhel, Alexander S.
影响因子：
4.4
作者：
Aksoy, Emre;Telleria, Erich L.;Caccone, Adalgisa
通讯作者：
Caccone, Adalgisa