Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study.
Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study.
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DOI：
10.1093/infdis/jiy443
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发表时间：
2019-01-09
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影响因子：
--
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中科院分区：
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了解流感感染的发病率和风险人群的患病比例是实施预防措施的关键。虽然之前已经描述了基于人群的抗血凝素抗体反应研究，但缺乏检查抗血凝素和抗神经氨酸酶抗体的研究。2015年，我们对从新西兰人群中随机选择的个体进行了血清流行病学队列研究。我们检测了配对血清的血凝抑制（HAI）或神经氨酸酶抑制（NAI）滴度，以确定血清转换。我们每周随访参与者，并对报告流感样疾病（ILI）的患者进行流感聚合酶链反应（PCR）。在911名未接种疫苗的参与者中，321名（35% [95%置信区间，32%-38%]）发现流感感染（HAI或NAI血清转化），其中100名（31%）仅血清转化为NAI。幼儿和太平洋岛屿人经历了最高的流感感染发病率，但总体而言，只有四分之一的感染者报告了经PCR证实的流感ILI，其中四分之一寻求医疗照顾。在<5岁的儿童中，单独的NAI血清转化率高于年龄≥5岁的儿童（14%比4%; P < .001），在B型流感病毒感染者中，单独的NAI血清转化率高于A型流感病毒感染者（7%比0.3%; P < .001）。除抗血凝素抗体外，抗神经氨酸酶抗体的测量对于获得真实的流感感染率可能很重要。
Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of antihemagglutinin antibody responses have been described previously, studies examining both antihemagglutinin and antineuraminidase antibodies are lacking. In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI). Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%–38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR–confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001). Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates.
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影响因子：
4.4
作者：
Huang QS;Turner N;Baker MG;Williamson DA;Wong C;Webby R;Widdowson MA
通讯作者：
Widdowson MA
影响因子：
6.2
作者：
Johansson, Bert E.;Cox, Manon M. J.
通讯作者：
Cox, Manon M. J.
影响因子：
5
作者：
ELVEBACK, LR;FOX, JP;HALL, CE
通讯作者：
HALL, CE
影响因子：
64.8
作者：
Everitt, Aaron R.;Clare, Simon;Pertel, Thomas;John, Sinu P.;Wash, Rachael S.;Smith, Sarah E.;Chin, Christopher R.;Feeley, Eric M.;Sims, Jennifer S.;Adams, David J.;Wise, Helen M.;Kane, Leanne;Goulding, David;Digard, Paul;Anttila, Verneri;Baillie, J. Kenneth;Walsh, Tim S.;Hume, David A.;Palotie, Aarno;Xue, Yali;Colonna, Vincenza;Tyler-Smith, Chris;Dunning, Jake;Gordon, Stephen B.;Smyth, Rosalind L.;Openshaw, Peter J.;Dougan, Gordon;Brass, Abraham L.;Kellam, Paul
通讯作者：
Kellam, Paul
DOI：
10.1086/657084
发表时间：
2010-12-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Marcelin G;Bland HM;Negovetich NJ;Sandbulte MR;Ellebedy AH;Webb AD;Griffin YS;DeBeauchamp JL;McElhaney JE;Webby RJ
通讯作者：
Webby RJ