Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner.

Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner.
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DOI:
10.1086/657084
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发表时间:
2010-12-01
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Webby RJ
Webby RJ
中科院分区:
其他
文献类型:
--
作者:
Marcelin G;Bland HM;Negovetich NJ;Sandbulte MR;Ellebedy AH;Webb AD;Griffin YS;DeBeauchamp JL;McElhaney JE;Webby RJ

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针对2009年甲型H1N1流感病毒血凝素(pH 1 N1)的既存抗体与年龄呈正相关。目前季节性流感疫苗对建立对其他pH 1 N1蛋白的免疫力的影响尚不清楚。我们测量了成年人接种季节性三价灭活流感疫苗前后血清中H1N1大流行性神经氨酸酶(pNA)抗体。在所有年龄组中均观察到pNA血清抗体;然而,接种疫苗主要在老年人中升高pNA抗体。因此,当代季节性疫苗可能有助于减少老年人的pH 1 N1相关疾病。
Pre-existing antibodies to the hemagglutinin of pandemic A (H1N1) 2009 influenza virus (pH1N1) positively correlates with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pH1N1 proteins is unknown. We measured serum antibodies to the neuraminidase of pandemic H1N1 (pNA) in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pNA were observed in all age groups; however, vaccination elevated pNA antibodies in predominately the elderly. Therefore, contemporary seasonal vaccines likely contribute to reduction of pH1N1 associated disease in older individuals.
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