Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner.
Inactivated seasonal influenza vaccines increase serum antibodies to the neuraminidase of pandemic influenza A(H1N1) 2009 virus in an age-dependent manner.
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DOI:
10.1086/657084
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发表时间:
2010-12-01
期刊:
影响因子:
--
通讯作者:
Webby RJ
中科院分区:
文献类型:
--
作者:
Marcelin G;Bland HM;Negovetich NJ;Sandbulte MR;Ellebedy AH;Webb AD;Griffin YS;DeBeauchamp JL;McElhaney JE;Webby RJ
Pre-existing antibodies to the hemagglutinin of pandemic A (H1N1) 2009 influenza virus (pH1N1) positively correlates with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pH1N1 proteins is unknown. We measured serum antibodies to the neuraminidase of pandemic H1N1 (pNA) in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pNA were observed in all age groups; however, vaccination elevated pNA antibodies in predominately the elderly. Therefore, contemporary seasonal vaccines likely contribute to reduction of pH1N1 associated disease in older individuals.
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影响因子:
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作者:
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通讯作者:
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DOI:
10.4161/hv.3.5.4175
发表时间:
2007-09-01
期刊:
HUMAN VACCINES
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