Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis
Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis
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类风湿关节炎气道疾病和间质性肺疾病的相关因素
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
J. Choe
中科院分区：
文献类型：
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作者：
Ji;Hwajeong Lee;J. Hwang;Sung;Hyesun Lee;Seong;J. Choe
目标。本研究检查了类风湿性关节炎（RA）患者的肺部受累情况，并确定了与气道疾病（AD）和间质性肺疾病（ILD）相关的因素。方法。共有507名RA患者参加了一项横断面研究。通过高分辨率计算机断层扫描评估肺部受累情况。患者按正常、AD和ILD进行分组。进行多项逻辑回归分析以确定与AD和ILD相关的因素。结果。最常见的肺部受累是AD(38.3%)，其次是ILD（12.6%）。老年AD(调整优势比（aOR） 2.58, 95%可信区间（CI） 1.70 ~ 3.90；aOR 4.38， ILD为95% CI 2.30 - 8.35)、男性（AD为aOR 2.57, 95% CI 1.22 - 5.42； ILD为aOR 5.48, 95% CI 2.20 - 13.65）是与RA患者AD和ILD相关的因素。ILD与病程短相关（aOR 0.30, 95% CI 0.14 ~ 0.62）， AD与抗环瓜氨酸肽抗体高滴度相关（抗ccp； aOR 1.61, 95% CI 1.07 ~ 2.44）。结论。AD是RA患者中最常见的肺部累及。老年和男性均与AD和ILD相关。病程短与ILD相关。抗ccp抗体滴度高与AD相关。（中华风湿病杂志2016；23:101-108）
Objective. This study examined lung involvement in patients with rheumatoid arthritis (RA) and identified factors associated with airway disease (AD) and interstitial lung disease (ILD). Methods. A total of 507 RA patients were enrolled in a cross-sec- tional study. Lung involvement was assessed by high-resolution computed tomography scan. The patient groups were classified according to normal, AD, and ILD. Multinomial logistic regression analysis was performed to identify factors associated with AD and ILD. Results. The most frequent lung involvement was AD (38.3%) followed by ILD (12.6%). Old age (adjust odds ratio (aOR) 2.58, 95% confidence interval (CI) 1.70 to 3.90 for AD; aOR 4.38, 95% CI 2.30 to 8.35 for ILD), male gender (aOR 2.57, 95% CI 1.22 to 5.42 for AD; aOR 5.48, 95% CI 2.20 to 13.65 for ILD) were factors associated with AD and ILD in RA patients. ILD was associated with short disease duration (aOR 0.30, 95% CI 0.14 to 0.62), AD was associated with high titers of anti-cy- clic citrullinated peptides antibodies (anti-CCP; aOR 1.61, 95% CI 1.07 to 2.44). Conclusion. AD was the most frequent lung involvement in patients with RA. Old age and male gender were both associated with AD and ILD. Short disease duration was associated with ILD. High titers of anti-CCP was associated with AD. (J Rheum Dis 2016;23:101-108)
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影响因子：
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作者：
Saag, KG;Kolluri, S;Schwartz, DA
通讯作者：
Schwartz, DA
类风湿性关节炎间质性肺疾病的发病率和死亡率：一项基于人群的研究。
影响因子：
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作者：
Bongartz, Tim;Nannini, Carlotta;Medina-Velasquez, Yimy F.;Achenbach, Sara J.;Crowson, Cynthia S.;Ryu, Jay H.;Vassallo, Robert;Gabriel, Sherine E.;Matteson, Eric L.
通讯作者：
Matteson, Eric L.
影响因子：
15.9
作者：
Rangel-Moreno, Javier;Hartson, Louise;Randall, Troy D.
通讯作者：
Randall, Troy D.
影响因子：
9.6
作者：
Kim, Eunice J.;Collard, Harold R.;King, Talmadge E., Jr.
通讯作者：
King, Talmadge E., Jr.
影响因子：
4.3
作者：
Fischer, Aryeh;Solomon, Joshua J.;du Bois, Roland M.;Deane, Kevin D.;Olson, Amy L.;Fernandez-Perez, Evans R.;Huie, Tristan J.;Stevens, Allen D.;Gill, Mary B.;Rabinovitch, Avi M.;Lynch, David A.;Burns, David A.;Pineiro, Isabel S.;Groshong, Steve D.;Achcar, Rosane D. Duarte;Brown, Kevin K.;Martin, Richard J.;Swigris, Jeffrey J.
通讯作者：
Swigris, Jeffrey J.