Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.
Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.
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DOI:
10.1002/anie.201208331
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发表时间:
2013-01-28
影响因子:
16.6
通讯作者:
Bawendi, Moungi
中科院分区:
文献类型:
--
作者:
Han, Hee-Sun;Martin, John D.;Lee, Jungmin;Harris, Daniel K.;Fukumura, Dai;Jain, Rakesh K.;Bawendi, Moungi
Detailed Charge arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influence nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.
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