Neural correlates of social approach and withdrawal in patients with major depression.
Neural correlates of social approach and withdrawal in patients with major depression.
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DOI：
10.1080/17470919.2011.579800
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发表时间：
2011
影响因子：
2
通讯作者：
Habel U
中科院分区：
文献类型：
--
作者：
Derntl B;Seidel EM;Eickhoff SB;Kellermann T;Gur RC;Schneider F;Habel U
成功的人际互动建立在对面部情感的正确识别、解释和适当反应的基础上。在抑郁症中，社交技能缺陷是导致社交退缩的最具抑制力的症状之一，从而加剧了社交孤立和抑郁情绪。情绪刺激的功能障碍和退缩倾向已被记录在案，但对其神经基础的研究受到的关注有限。我们进行了一项功能磁共振研究，其中包括15名抑郁症患者和15名匹配的健康对照。所有受试者都完成了两个任务，一个是内隐的操纵杆任务，另一个是明确的评级任务，这两个任务都使用了高兴、中性和愤怒的面部表情。行为数据分析表明存在显著的群体效应，抑郁症患者表现出比对照组更多的退缩。对功能数据的分析显示，这两项任务都存在显著的群体效应。在其他区域中，我们观察到杏仁核激活的显著差异，患者表现出较少的反应，特别是在接近快乐面孔的时候。此外，杏仁核的激活与精神病理之间出现了显著的相关性，这表明症状越明显，杏仁核激活的减少就越明显。因此，我们的结果表明，抑郁症患者表现出功能障碍的社交方式和退缩行为，这反过来可能会通过导致孤立和强化认知偏差的负面社会互动而加剧障碍。
Successful human interaction is based on correct recognition, interpretation and appropriate reaction to facial affect. In depression, social skill deficits are among the most restraining symptoms leading to social withdrawal, thereby aggravating social isolation and depressive affect. Dysfunctional approach and withdrawal tendencies towards emotional stimuli have been documented but the investigation of their neural underpinnings has received limited attention. We performed an fMRI study including 15 depressive patients and 15 matched healthy controls. All subjects performed two tasks, an implicit joystick task as well as an explicit rating task both using happy, neutral, and angry facial expressions. Behavioral data analysis indicated a significant group effect, with depressed patients showing more withdrawal than controls. Analysis of the functional data revealed significant group effects for both tasks. Amongst other regions, we observed significant group differences in amygdala activation with patients showing less response particularly during approach of happy faces. Additionally, significant correlations of amygdala activation with psychopathology emerged, suggesting that more pronounced symptoms are accompanied by stronger decreases of amygdala activation. Hence, our results demonstrate that depressed patients show dysfunctional social approach and withdrawal behavior, which in turn may aggravate the disorder by negative social interactions contributing to isolation and reinforcing cognitive biases.
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影响因子：
6.6
作者：
Bouhuys, AL;Geerts, E;Mersch, PPA
通讯作者：
Mersch, PPA
影响因子：
11.3
作者：
Bouhuys, AL;Geerts, E;Jenner, JA
通讯作者：
Jenner, JA
影响因子：
4
作者：
Chen, M;Bargh, JA
通讯作者：
Bargh, JA
DOI：
10.1073/pnas.0935845100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Carr, L;Iacoboni, M;Lenzi, GL
通讯作者：
Lenzi, GL
影响因子：
3.5
作者：
Ackermann, Hermann;Mathiak, Klaus;Riecker, Axel
通讯作者：
Riecker, Axel