Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants.
Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants.
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DOI：
10.3389/fnhum.2021.721076
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发表时间：
2021
影响因子：
2.9
通讯作者：
Wang DD
中科院分区：
文献类型：
--
作者：
Burke JF;Kunwar N;Yaroshinsky MS;Louie KH;Shirvalkar P;Su P;Henry M;Pasvankas G;Poree L;Jacques L;Wang DD
对人类自主运动控制过程中脊髓的电生理活动知之甚少。我们提出了一种新的方法，使用植入的硬膜外电极记录包括地面行走在内的自然运动中人类脊髓的电生理活动。作为对接受脊髓刺激评估的慢性疼痛患者的测试试验的一部分，从植入的硬膜外电极记录了脊髓电信号(SEG)。硬膜外引线的外置末端连接到外部放大器以捕获SEGS。使用无线传感器收集上肢和下肢的肌电和加速度计数据，并与SEG数据同步。指导患者进行不同的手臂和腿部运动，同时收集SEG和运动学数据。这项研究证明了对执行运动任务的受试者进行硬膜外脊椎记录的安全性和可行性。
Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidural electrodes during naturalistic movements including overground walking. Spinal electrograms (SEGs) were recorded from epidural electrodes implanted as part of a test trial for patients with chronic pain undergoing evaluation for spinal cord stimulation. Externalized ends of the epidural leads were connected to an external amplifier to capture SEGs. Electromyographic and accelerometry data from the upper and lower extremities were collected using wireless sensors and synchronized to the SEG data. Patients were instructed to perform various arm and leg movements while SEG and kinematic data were collected. This study proves the safety and feasibility of performing epidural spinal recordings from human subjects performing movement tasks.
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影响因子：
5.3
作者：
Burke, John F.;Sharan, Ashwini D.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Wagner, Fabien B.;Mignardot, Jean-Baptiste;Courtine, Gregoire
通讯作者：
Courtine, Gregoire
DOI：
10.1111/j.1749-6632.1998.tb09062.x
发表时间：
1998-01-01
期刊：
NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY
影响因子：
--
作者：
Dimitrijevic, MR;Gerasimenko, Y;Pinter, MM
通讯作者：
Pinter, MM
影响因子：
3.7
作者：
Ramos-Murguialday A;Schürholz M;Caggiano V;Wildgruber M;Caria A;Hammer EM;Halder S;Birbaumer N
通讯作者：
Birbaumer N