The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents.
The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents.
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DOI：
10.3390/molecules22122071
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发表时间：
2017-12-13
期刊：
影响因子：
--
通讯作者：
Lukic ML
中科院分区：
文献类型：
--
作者：
Pantic JM;Jovanovic IP;Radosavljevic GD;Arsenijevic NN;Conlon JM;Lukic ML
本文综述了蛙皮源肽的免疫调节作用，以评估其作为免疫调节或抗炎治疗候选药物的潜力。具有明显免疫调节特性的蛙皮肽已经从属于Alytidae、Ascaphidae、Discoglossidae、Leptodactylidae、Pipidae和Ranidae的一系列物种的皮肤分泌物中分离。它们对靶细胞产生炎性和免疫调节细胞因子的影响已经离体评价，并且在注射到小鼠中后通过流式细胞术在体内研究了对细胞因子表达和免疫细胞活性的影响。天然存在的肽和/或其合成类似物对外周细胞和脾细胞、腹膜细胞和/或分离的巨噬细胞产生促炎性（TNF-α、IL-1β、IL-12、IL-23、IL-8、IFN-γ和IL-17）、多效性（IL-4和IL-6）和免疫抑制性（IL-10和TGF-β）细胞因子显示出复杂和可变的作用。frenatin 2.1S的作用包括增强小鼠腹腔中Th 1型淋巴细胞和NK细胞的活化状态和归巢能力，以及促进其杀肿瘤能力。总体而言，青蛙皮肤衍生肽对免疫系统的不同作用表明其开发为治疗剂的潜力。
The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions of a range of species belonging to the families Alytidae, Ascaphidae, Discoglossidae, Leptodactylidae, Pipidae and Ranidae. Their effects upon production of inflammatory and immunoregulatory cytokines by target cells have been evaluated ex vivo and effects upon cytokine expression and immune cell activity have been studied in vivo by flow cytometry after injection into mice. The naturally-occurring peptides and/or their synthetic analogues show complex and variable actions on the production of proinflammatory (TNF-α, IL-1β, IL-12, IL-23, IL-8, IFN-γ and IL-17), pleiotropic (IL-4 and IL-6) and immunosuppressive (IL-10 and TGF-β) cytokines by peripheral and spleen cells, peritoneal cells and/or isolated macrophages. The effects of frenatin 2.1S include enhancement of the activation state and homing capacity of Th1-type lymphocytes and NK cells in the mouse peritoneal cavity, as well as the promotion of their tumoricidal capacities. Overall, the diverse effects of frog skin-derived peptides on the immune system indicate their potential for development into therapeutic agents.
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影响因子：
3
作者：
Conlon, J. Michael;Al-Ghafari, Nadia;Davidson, Carlos
通讯作者：
Davidson, Carlos
影响因子：
3.5
作者：
Conlon, J. Michael;Mechkarska, Milena;Attoub, Samir
通讯作者：
Attoub, Samir
影响因子：
3
作者：
Conlon, J. Michael;Mechkarska, Milena;McClean, Stephen
通讯作者：
McClean, Stephen
DOI：
10.1016/j.cbd.2013.10.002
发表时间：
2013-12-01
影响因子：
3
作者：
Conlon, J. Michael;Prajeep, Manju;King, Jay D.
通讯作者：
King, Jay D.
影响因子：
--
作者：
Conlon, J. Michael;Power, Gavin J.;Vaudry, Hubert
通讯作者：
Vaudry, Hubert