Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.
Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.
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DOI：
10.1002/mrm.26994
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发表时间：
2018-07
影响因子：
3.3
通讯作者：
Nayak KS
中科院分区：
文献类型：
--
作者：
Jao TR;Nayak KS
通过延迟是心力衰竭或有侧支循环的心脏ASL的潜在错误来源。本研究证明了使用传输延迟不敏感的速度选择ASL的可行性，并将其性能与FAIR ASL进行比较。使用绝热BIR 8制备实现速度选择性标记。在10名健康志愿者（1名女性/9名男性，年龄23-30岁）中进行了FAIR和VSASL，具有不同的速度截止值（VC=10-40 cm/s）和标记方向（前-后X，侧-间隔Y和顶部-基底Z）。测量心肌血流量（MBF）和时间信噪比（TSNR）。VSASL对灌注的敏感性随着VC的增加而降低。在低VC（< 5 cm/s）时，出现心肌伪标记并高估MBF。在Z中VC为10 cm/s时，FAIR（1.12±0.26 ml/g/min）和VASL（1.26±0.27 ml/g/min）测量的MBF相当（TOST差异为0.30 ml/g/min，p=0.049）。FAIR的TSNR（13.62±5.25）是VSASL（4.87±1.58）的2.8倍。VSASL对Y方向的灌注不敏感。X和Z表现相似，TSNR分别为4.17±2.32和3.97±0.56。VSASL是FAIR ASL的一个有前途的替代方案，非常适合运输延误时间较长的情况。
Transit delay is a potential source of error in cardiac ASL in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with FAIR ASL. Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and VSASL with various velocity cutoffs (VC=10–40 cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were performed in 10 healthy volunteers (1F/9M age 23–30). Myocardial blood flow (MBF) and temporal SNR (TSNR) were measured. VSASL sensitivity to perfusion decreased with increasing VC. At low VC (< 5 cm/s), spurious labeling of myocardium occurs and overestimates MBF. MBF measured with FAIR (1.12±0.26 ml/g/min) and VASL (1.26±0.27 ml/g/min) at VC of 10 cm/s in Z were comparable (TOST with difference of 0.30 ml/g/min, p=0.049). TSNR was 2.8 times larger using FAIR (13.62±5.25) than in VSASL (4.87±1.58). VSASL was insensitive to perfusion in the Y direction. X and Z performed similarly with TSNR of 4.17±2.32 and 3.97±0.56 respectively. VSASL is a promising alternative to FAIR ASL in the heart and is well suited for scenarios when transit delays are long.
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影响因子：
3.3
作者：
Keith GA;Rodgers CT;Chappell MA;Robson MD
通讯作者：
Robson MD
影响因子：
37.8
作者：
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通讯作者：
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影响因子：
10.8
作者：
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影响因子：
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作者：
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通讯作者：
Arai, AE
影响因子：
3.3
作者：
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通讯作者：
Jezzard, Peter