A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla.
A look-locker acquisition scheme for quantitative myocardial perfusion imaging with FAIR arterial spin labeling in humans at 3 tesla.
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DOI：
10.1002/mrm.26388
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发表时间：
2017-08
影响因子：
3.3
通讯作者：
Robson MD
中科院分区：
文献类型：
--
作者：
Keith GA;Rodgers CT;Chappell MA;Robson MD
介绍了一种在单次屏气中使用动脉自旋标记（ASL）定量测量心肌血流量（MBF）的新方法，通过模拟、体模研究和体内研究进行了评价，并测试了重现性和变异性。在3特斯拉下实施具有Look-Resistance读出（LL-FAIR-ASL）的流动敏感交替反转恢复（FAIR）ASL方法。对10名健康志愿者进行扫描，并在三个切片中测量MBF。通过Bland-Altman分析和统计学测量研究了该方法的重现性，并报告了重现性系数（CR）和变异系数（CV）。基底、中间和顶端切片的MBF值分别为1.04 ± 0.40、1.06 ± 0.46和1.06 ± 0.38 ml/g/min（平均值± SD），与文献值相当。对于心室中部切片，所有扫描的CV（43%）均大于会话间和会话内值（分别为16%和13%）。对于心室中部，检测所需的MBF变化（相对于CR）在会话之间为61%，会话内为53%。本研究显示了LL‐FAIR‐ASL方法定量MBF的可行性。报告的统计措施将允许规划未来的临床研究，包括休息和压力测量。Magn Reson Med 78：541-549，2017。© 2016 The Authors Magnetic Resonance in Medicine出版由Wiley Periodicals，Inc.国际医学磁共振学会（International Society for Magnetic Resonance in Medicine）这是一个开放获取的条款下的知识共享署名许可证，允许使用，分发和复制在任何媒体上，只要原始作品是适当的引用。
A novel method for quantitative measurement of myocardial blood flow (MBF) using arterial spin labeling (ASL) in a single breath‐hold is presented, evaluated by simulations, phantom studies and in vivo studies and tested for reproducibility and variability. A flow‐sensitive alternating inversion recovery (FAIR) ASL method with Look‐Locker readout (LL‐FAIR‐ASL) was implemented at 3 tesla. Scans were performed on 10 healthy volunteers and MBF measured in three slices. The method was investigated for reproducibility by Bland‐Altman analysis and statistical measures, the coefficients of reproducibility (CR) and variation (CV) are reported. The MBF values for the basal, mid, and apical slices were 1.04 ± 0.40, 1.06 ± 0.46, and 1.06 ± 0.38 ml/g/min, respectively (mean ± SD), which compare well with literature values. The CV across all scans, 43%, was greater than the between‐session and within‐session values, at 16 and 13%, respectively, for the mid‐ventricular slice. The change in MBF required for detection, from the CR, was 61% between‐session and 53% within‐session for the mid‐ventricle. This study shows the feasibility of the LL‐FAIR‐ASL method for the quantification of MBF. The statistical measures reported will allow the planning of future clinical research studies involving rest and stress measurements. Magn Reson Med 78:541–549, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
10.8
作者：
Chareonthaitawee, P;Kaufmann, PA;Camici, PG
通讯作者：
Camici, PG
影响因子：
4.4
作者：
Hsu, LY;Rhoads, KL;Arai, AE
通讯作者：
Arai, AE
影响因子：
9.3
作者：
Manabe, Osamu;Yoshinaga, Keiichiro;Tamaki, Nagara
通讯作者：
Tamaki, Nagara
DOI：
10.1007/s00259-007-0478-2
发表时间：
2007-11-01
影响因子：
9.1
作者：
Lortie, Mireille;Beanlands, Rob S. B.;dekemp, Robert A.
通讯作者：
dekemp, Robert A.