Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion.
Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion.
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DOI：
10.1038/s41598-018-26054-8
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发表时间：
2018-05-16
影响因子：
4.6
通讯作者：
Hasegawa I
中科院分区：
文献类型：
--
作者：
Toda H;Kawasaki K;Sato S;Horie M;Nakahara K;Bepari AK;Sawahata H;Suzuki T;Okado H;Takebayashi H;Hasegawa I
特定频率的振荡放电活动在分布式皮层网络中起着重要的作用。然而，有这样的频率特异性信号是如何诱导或传播信号的信号频谱是如何调制跨层（径向）和区域间（切向）神经元相互作用的证据有限。为了直接评估尖峰皮层网络的光谱变化的方向特异性，我们选择性地光刺激在大鼠初级视觉皮层（V1）的颗粒下兴奋性神经元在阈上水平与各种频率，并记录局部场电位（LFPs）在颗粒下刺激部位，皮质表面网站上的刺激网站V1，和V1以外的皮质表面网站。我们发现径向传播过程中，特别是在高频刺激条件下，LFP功率显着降低。此外，低伽马波段主导的节奏是瞬时诱导径向传播过程中。相比之下，区域间LFP传播，针对特定的皮质部位，伴随着没有显着的信号减少，也没有伽玛波段功率感应。我们提出了一个各向异性的机制，在尖峰皮层网络的信号处理，其中的神经元的节奏是局部诱导/调制沿着径向方向，然后传播无失真通过内在的水平连接时空精确，区域间的通信。
Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and inter-areal (tangential) neuronal interactions. To directly evaluate the direction specificity of spectral changes in a spiking cortical network, we selectively photostimulated infragranular excitatory neurons in the rat primary visual cortex (V1) at a supra-threshold level with various frequencies, and recorded local field potentials (LFPs) at the infragranular stimulation site, the cortical surface site immediately above the stimulation site in V1, and cortical surface sites outside V1. We found a significant reduction of LFP powers during radial propagation, especially at high-frequency stimulation conditions. Moreover, low-gamma-band dominant rhythms were transiently induced during radial propagation. Contrastingly, inter-areal LFP propagation, directed to specific cortical sites, accompanied no significant signal reduction nor gamma-band power induction. We propose an anisotropic mechanism for signal processing in the spiking cortical network, in which the neuronal rhythms are locally induced/modulated along the radial direction, and then propagate without distortion via intrinsic horizontal connections for spatiotemporally precise, inter-areal communication.
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影响因子：
2.9
作者：
Kahn I;Knoblich U;Desai M;Bernstein J;Graybiel AM;Boyden ES;Buckner RL;Moore CI
通讯作者：
Moore CI
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R
影响因子：
3.4
作者：
Bedard, Claude;Destexhe, Alain
通讯作者：
Destexhe, Alain
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.