The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study.
The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study.
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台湾人群中1型和2型白细胞介素1受体基因多态性与突发性感音神经性听力损失的关系：一项病例对照研究。
DOI：
10.1186/s40463-021-00550-w
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发表时间：
2021-12-05
期刊：
影响因子：
--
通讯作者：
Chang NC
中科院分区：
文献类型：
--
作者：
Chien CY;Tai SY;Li KH;Yang HL;Chan LP;Hsi E;Wang LF;Ho KY;Chang NC
突发性感音神经性听力损失（SSNHL）是一种病因不明的疾病；由于病毒感染或血管事件引起的炎症对听神经的损害已被牵连。根据多项研究，包括白细胞介素在内的细胞因子在血清表达和遗传多态性方面与SSNHL相关。白细胞介素-1 （IL-1）在炎症中起关键作用，可能与SSNHL有关。本研究分析台湾地区IL-1受体（IL-1R）基因单核苷酸多态性（snp）与SSNHL的关系。我们进行了一项涉及401例SSNHL患者和730名健康对照者的病例对照研究。筛选出4个snp （IL-1R 1型基因[IL1R1] [rs3917225和rs2234650]和IL-1R 2型基因[IL1R2] [rs4141134和rs2071008]）。采用TaqMan法测定基因型。检测每个SNP的Hardy-Weinberg平衡（HWE），并评估遗传效应。与SSNHL患者的CC基因型相比，rs2234650的TT基因型校正优势比（OR）为2.988(95%可信区间[95% CI] 1.27 ~ 6.82) （P = 0.012）。SNP rs2234650在隐性模型中与SSNHL相关（TT vs. CC + CT, P = 0.0206, OR = 2.681）。在SSNHL患者中，rs4141134的CT基因型与TT基因型的校正OR为3.860 （95% CI 2.01-7.44; P < 0.0001）。优势模型下SNP rs4141134与SSNHL相关（CC + CT vs. TT, P < 0.0001, OR = 4.087）。这些发现提示，IL1R1和IL1R2基因多态性可能与台湾SSNHL的风险增加有关。
Sudden sensorineural hearing loss (SSNHL) is a disease with an unknown etiology; damage to the auditory nerve from inflammation due to viral infection or vascular incidents has been implicated. According to several studies, cytokines, including interleukins, are associated with SSNHL in terms of serum expression and genetic polymorphisms. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with SSNHL. This study analyzed the association of single nucleotide polymorphisms (SNPs) of IL-1 receptor (IL-1R) genes with SSNHL in Taiwan. We conducted a case–control study involving 401 patients with SSNHL and 730 healthy controls. Four SNPs (IL-1R type 1 gene [IL1R1] [rs3917225 and rs2234650] and IL-1R type 2 gene [IL1R2] [rs4141134 and rs2071008]) were selected. The genotypes were determined using the TaqMan assay. The Hardy–Weinberg equilibrium (HWE) was tested for each SNP, and genetic effects were evaluated. The TT genotype of rs2234650 had an adjusted odds ratio (OR) of 2.988 (95% confidence interval [95% CI] 1.27–6.82) (P = 0.012) compared with the CC genotype in patients with SSNHL. The SNP rs2234650 was associated with SSNHL in the recessive model (TT vs. CC + CT, P = 0.0206, OR = 2.681). The CT genotype of rs4141134 had an adjusted OR of 3.860 (95% CI 2.01–7.44; P < 0.0001) compared with the TT genotype, in patients with SSNHL. The SNP rs4141134 was associated with SSNHL under the dominant model (CC + CT vs. TT, P < 0.0001, OR = 4.087). These findings suggest that IL1R1 and IL1R2 gene polymorphisms may contribute to an increased risk of SSNHL in Taiwan.
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影响因子：
3.7
作者：
Rhodes DM;Smith SA;Holcombe M;Qwarnstrom EE
通讯作者：
Qwarnstrom EE
影响因子：
1.7
作者：
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Chang, Ning-Chia;Yang, Hua-Ling;Ho, Kuen-Yao
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Ho, Kuen-Yao
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1.6
作者：
Kassner, Stefan S.;Schoettler, Sarah;Goessler, Ulrich R.
通讯作者：
Goessler, Ulrich R.
影响因子：
24.1
作者：
Vasilyev, F. F.;Silkov, A. N.;Sennikov, S. V.
通讯作者：
Sennikov, S. V.