Historical exposure to chemicals reduces tolerance to novel chemical stress in Daphnia (waterflea).
Historical exposure to chemicals reduces tolerance to novel chemical stress in Daphnia (waterflea).
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DOI：
10.1111/mec.16451
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发表时间：
2022-06
影响因子：
4.9
通讯作者：
Orsini, Luisa
中科院分区：
文献类型：
--
作者：
Abdullahi, Muhammad;Zhou, Jiarui;Dandhapani, Vignesh;Chaturvedi, Anurag;Orsini, Luisa
直到最近几十年，大多数生产过程中使用的人为化学品尚未就其对野生动物和人类的风险和影响进行全面评估。它们被输送到全球，通常以无意污染物的形式最终进入环境，造成长期的不利影响。现代毒理学实践通常使用不切实际的化学品浓度的急性毒性测试来确定其安全使用，从而忽略了长期暴露于环境相关浓度所产生的病理影响。在这里，我们研究了五种与环境相关的化学物质浓度对关键物种大型水蚤国际监管框架优先列表的跨代影响。我们将从一个有已知化学污染历史的湖泊的沉积档案中复活的水蚤基因型别暴露在这五种化学物质中，以了解历史上接触化学物质如何影响对新化学物质应激的适应反应。我们测量了在“有经验的”和“幼稚的”基因暴露于新的化学压力后，与健康相关的生活史特征的代内和跨代可塑性。由于复活的水蚤起源于过去不同时间采样的同一基因库，我们能够通过研究全基因组多样性和识别受历史化学胁迫影响的功能途径来量化化学污染的长期进化影响。我们的结果表明，历史上暴露在化学压力下会导致全基因组多样性降低，导致对新的化学压力的跨代耐受性降低。较低的耐受性是由经历过的基因型中解毒、分解代谢和内分泌基因的基因多样性降低所支撑的。我们表明，这些基因位于其他物种(包括人类)中保守的和潜在的化学靶标的途径中。
Until the last few decades, anthropogenic chemicals used in most production processes have not been comprehensively assessed for their risk and impact on wildlife and humans. They are transported globally and usually end up in the environment as unintentional pollutants, causing long‐term adverse effects. Modern toxicology practices typically use acute toxicity tests of unrealistic concentrations of chemicals to determine their safe use, missing pathological effects arising from long‐term exposures to environmentally relevant concentrations. Here, we study the transgenerational effect of environmentally relevant concentrations of five chemicals on the priority list of international regulatory frameworks on the keystone species Daphnia magna. We expose Daphnia genotypes resurrected from the sedimentary archive of a lake with a known history of chemical pollution to the five chemicals to understand how historical exposure to chemicals influences adaptive responses to novel chemical stress. We measure within‐ and transgenerational plasticity in fitness‐linked life history traits following exposure of “experienced” and “naive” genotypes to novel chemical stress. As the revived Daphnia originate from the same genetic pool sampled at different times in the past, we are able to quantify the long‐term evolutionary impact of chemical pollution by studying genome‐wide diversity and identifying functional pathways affected by historical chemical stress. Our results suggest that historical exposure to chemical stress causes reduced genome‐wide diversity, leading to lower cross‐generational tolerance to novel chemical stress. Lower tolerance is underpinned by reduced gene diversity at detoxification, catabolism and endocrine genes in experienced genotypes. We show that these genes sit within pathways that are conserved and potential chemical targets in other species, including humans.
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支持水蚤对多种压力源的适应性反应的进化机制。
影响因子：
4.1
作者：
Cuenca-Cambronero M;Pantel JH;Marshall H;Nguyen TTT;Tomero-Sanz H;Orsini L
通讯作者：
Orsini L
影响因子：
4.1
作者：
Cuenca Cambronero M;Zeis B;Orsini L
通讯作者：
Orsini L
影响因子：
9.8
作者：
Bai, Xuelian;Son, Yeongkwon
通讯作者：
Son, Yeongkwon
DOI：
10.1126/science.1197761
发表时间：
2011-02-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colbourne JK;Pfrender ME;Gilbert D;Thomas WK;Tucker A;Oakley TH;Tokishita S;Aerts A;Arnold GJ;Basu MK;Bauer DJ;Cáceres CE;Carmel L;Casola C;Choi JH;Detter JC;Dong Q;Dusheyko S;Eads BD;Fröhlich T;Geiler-Samerotte KA;Gerlach D;Hatcher P;Jogdeo S;Krijgsveld J;Kriventseva EV;Kültz D;Laforsch C;Lindquist E;Lopez J;Manak JR;Muller J;Pangilinan J;Patwardhan RP;Pitluck S;Pritham EJ;Rechtsteiner A;Rho M;Rogozin IB;Sakarya O;Salamov A;Schaack S;Shapiro H;Shiga Y;Skalitzky C;Smith Z;Souvorov A;Sung W;Tang Z;Tsuchiya D;Tu H;Vos H;Wang M;Wolf YI;Yamagata H;Yamada T;Ye Y;Shaw JR;Andrews J;Crease TJ;Tang H;Lucas SM;Robertson HM;Bork P;Koonin EV;Zdobnov EM;Grigoriev IV;Lynch M;Boore JL
通讯作者：
Boore JL
DOI：
10.3791/56637
发表时间：
2018-01-19
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Cuenca Cambronero M;Orsini L
通讯作者：
Orsini L