Spatiotemporal receptive fields of barrel cortex revealed by reverse correlation of synaptic input.
Spatiotemporal receptive fields of barrel cortex revealed by reverse correlation of synaptic input.
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DOI：
10.1038/nn.3720
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发表时间：
2014-06
影响因子：
25
通讯作者：
Bruno, Randy M.
中科院分区：
文献类型：
--
作者：
Ramirez, Alejandro;Pnevmatikakis, Eftychios A.;Merel, Josh;Paninski, Liam;Miller, Kenneth D.;Bruno, Randy M.
在所有的感觉区域中，桶状皮层是在电路方面被理解得最好的区域之一，但在感觉功能方面却被理解得最少。我们将大鼠的细胞内记录与一种新的多向多须刺激系统相结合，通过刺激与突触输入的反向相关来估计感受野。时空感受野的识别速度比传统的基于峰值的方法快了几个数量级，即使是对于几乎没有峰值活动的神经元也是如此。给定合适的刺激表示，线性模型以惊人的高准确度捕获了所有神经元的刺激-反应关系。与传统的单须刺激相比，复杂的刺激显示了显着的锐化的接受野，主要是由于适应。这一现象使得环绕能够促进而不是抑制对主晶须的响应。优化的刺激增强了第4-6层的放电，但没有2/3层，仍然保持稀疏的活跃。在自然感知过程中，可能需要通过适应来促进周围环境来辨别复杂的形状和纹理。
Of all sensory areas, barrel cortex is among the best understood in terms of circuitry, yet least understood in terms of sensory function. We combined intracellular recording in rats with a novel multi-directional multi-whisker stimulator system to estimate receptive fields by reverse correlation of stimuli to synaptic inputs. Spatiotemporal receptive fields were identified orders of magnitude faster than by conventional spike-based approaches, even for neurons with little spiking activity. Given a suitable stimulus representation, a linear model captured the stimulus-response relationship for all neurons with surprisingly high accuracy. In contrast to conventional single-whisker stimuli, complex stimuli revealed dramatically sharpened receptive fields, largely due to adaptation. This phenomenon allowed the surround to facilitate rather than suppress responses to the principal whisker. Optimized stimuli enhanced firing in layers 4-6 but not 2/3, which remained sparsely active. Surround facilitation through adaptation may be required for discriminating complex shapes and textures during natural sensing.
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