Review article: adherence to medication for chronic hepatitis C - building on the model of human immunodeficiency virus antiretroviral adherence research.
Review article: adherence to medication for chronic hepatitis C - building on the model of human immunodeficiency virus antiretroviral adherence research.
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DOI：
10.1111/j.1365-2036.2009.04004.x
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发表时间：
2009-07
影响因子：
7.6
通讯作者：
Fishbein D
中科院分区：
文献类型：
--
作者：
Weiss JJ;Bräu N;Stivala A;Swan T;Fishbein D
用聚乙二醇化干扰素/利巴韦林治疗丙型肝炎病毒感染，在高达56%的丙型肝炎病毒单一感染患者和40%的丙型肝炎病毒/人类免疫缺陷病毒(HIV)混合感染患者中实现了持续的病毒学应答。患者依从性与结果的关系值得研究。全面回顾丙型肝炎患者误服剂量治疗的研究，并从坚持HIV抗逆转录病毒治疗的角度讨论可应用的研究。使用关键词：依从性、依从性、丙型肝炎病毒、干扰素和利巴韦林，通过PubMed搜索来确定出版物。“不依从性”一词在丙型肝炎病毒中的使用方式与艾滋病毒文献中的不同。在丙型肝炎病毒中，“不坚持”主要是指临床医生减少剂量和早期停止治疗。相比之下，在艾滋病毒中，“不遵守”主要指的是患者错过的剂量。关于聚乙二醇化干扰素/利巴韦林的错过剂量依从率及其与病毒学应答的关系的数据很少发表。随着新型药物的出现，丙型肝炎病毒的治疗变得越来越复杂，对于治疗的成功，依从性将变得越来越重要，因为抗药性突变可能会随着丙型肝炎病毒酶抑制剂的次优剂量而发展。HIV依从性研究可以应用于丙型肝炎病毒的依从性研究，以建立准确的方法来评估依从性，调查不依从性的决定因素，并制定策略以优化依从性。
Treatment of hepatitis C virus (HCV) infection with pegylated interferon/ribavirin achieves sustained virological response in up to 56% of HCV mono-infected patients and 40% of HCV/human immunodeficiency virus (HIV)-co-infected patients. The relationship of patient adherence to outcome warrants study. To review comprehensively research on patient-missed doses to HCV treatment and discuss applicable research from adherence to HIV antiretroviral therapy. Publications were identified by PubMed searches using the keywords: adherence, compliance, hepatitis C virus, interferon and ribavirin. The term ‘non-adherence’ differs in how it is used in the HCV from the HIV literature. In HCV, ‘non-adherence’ refers primarily to dose reductions by the clinician and early treatment discontinuation. In contrast, in HIV, ‘non-adherence’ refers primarily to patient-missed doses. Few data have been published on the rates of missed dose adherence to pegylated interferon/ribavirin and its relationship to virological response. As HCV treatment becomes more complex with new classes of agents, adherence will be increasingly important to treatment success as resistance mutations may develop with suboptimal dosing of HCV enzyme inhibitors. HIV adherence research can be applied to that on HCV to establish accurate methods to assess adherence, investigate determinants of non-adherence and develop strategies to optimize adherence.
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影响因子：
3.8
作者：
Forton, DA;Allsop, JA;Taylor-Robinson, SD
通讯作者：
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影响因子：
--
作者：
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DOI：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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