Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes
Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes
复制标题
用于皮肤替代品的仿生 3D 涂层复合支架的开发和评估
DOI：
10.1002/mame.201900848
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发表时间：
2020-03
影响因子：
3.9
通讯作者：
Zhang Chuck
中科院分区：
文献类型：
--
作者：
Liu Sui-Hong;Zhang Hai-Guang;Hu Qing-Xi;Wang Ben;Li Shuai;Zhang Chuck
皮肤损伤是一个紧迫的健康问题，在临床上引起了极大的关注。尽管在过去的几十年中已经提出了许多策略来制造用于治疗伤口的皮肤替代物，但是制造理想的皮肤替代物来替代受损的皮肤仍然是一个问题。在这项研究中，一种新型的仿生三维复合皮肤支架的制造相结合的电流体动力学（EHD）喷射，静电纺丝，和涂层技术。这里，第一聚己内酯（PCL）多孔结构通过EHD喷射产生。接着，通过静电纺丝在PCL多孔结构上制备由纳米级纤维组成的第二聚乳酸（PLA）膜。PCL多孔结构和PLA纤维膜可分别模拟真皮层和表皮层。此外，明胶被用作涂层溶液，以增强支架的生物相容性。对制备的支架进行了结构和形貌分析，并对其力学性能进行了研究。此外，体外和体内实验证明了材料和制造工艺的生物相容性。总之，这些结果表明，复合支架是有效的，并在临床上具有巨大的皮肤再生潜力。
Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.
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影响因子：
10
作者：
Tao Xu;Jacob M. Miszuk;Yong Zhao;Hongli Sun;H. Fong
通讯作者：
Tao Xu;Jacob M. Miszuk;Yong Zhao;Hongli Sun;H. Fong
氧掺杂氮化硼纳米粒子的制备及其室温铁磁性研究
影响因子：
9.5
作者：
Lu, Qing;Zhao, Qi;Zhang, Mingzhe
通讯作者：
Zhang, Mingzhe
DOI：
10.1016/j.msec.2012.12.015
发表时间：
2013-04-01
影响因子：
7.9
作者：
Gautam, Sneh;Dinda, Amit Kumar;Mishra, Narayan Chandra
通讯作者：
Mishra, Narayan Chandra
DOI：
10.1016/j.jmbbm.2011.08.016
发表时间：
2012-01-01
影响因子：
3.9
作者：
Annaidh, Aisling Ni;Bruyere, Karine;Ottenio, Melanie
通讯作者：
Ottenio, Melanie
影响因子：
2.7
作者：
S. Vijayavenkataraman;Shuo Zhang;W. Lu;J. Fuh
通讯作者：
S. Vijayavenkataraman;Shuo Zhang;W. Lu;J. Fuh