Robustness and evolvability.
Robustness and evolvability.
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DOI：
10.1016/j.tig.2010.06.002
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发表时间：
2010-09
影响因子：
11.4
通讯作者：
Trotter, Meredith V.
中科院分区：
文献类型：
--
作者：
Masel, Joanna;Trotter, Meredith V.
为什么随机变异不总是有害的？有没有一些因素有时会使适应变得更容易？生物系统对突变、重组和环境的干扰具有非常强的鲁棒性。有人提出，这种鲁棒性可能使它们更容易进化。对突变的鲁棒性允许遗传变异以隐蔽状态积累。被称为进化电容器的转换机制意味着可遗传的表型变异的数量可以与压力的程度相关，从而与环境的新奇和剩余的适应潜力相关。有两个有点独立的文献有关的鲁棒性的进化。一个集中在分子表型和新的突变，另一个集中在形态学和隐藏的遗传变异。在这里，我们回顾了这两篇文献，并表明，真正的区别是重组率是高还是低。在这两种情况下，证据都支持鲁棒性促进进化性的说法。
Why isn’t random variation always deleterious? Are there factors that sometimes make adaptation easier? Biological systems are extraordinarily robust to perturbation by mutations, recombination, and the environment. It has been proposed that this robustness might make them more evolvable. Robustness to mutation allows genetic variation to accumulate in a cryptic state. Switching mechanisms known as evolutionary capacitors mean that the amount of heritable phenotypic variation available can be correlated to the degree of stress and hence to the novelty of the environment and remaining potential for adaptation. There have been two somewhat separate literatures relating robustness to evolvability. One has focused on molecular phenotypes and new mutations, the other on morphology and cryptic genetic variation. Here we review both literatures, and show that the true distinction is whether recombination rates are high or low. In both cases, the evidence supports the claim that robustness promotes evolvability.
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